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Journal of Neuroscience, Vol 12, 883-894, Copyright © 1992 by Society for Neuroscience
Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey
PM Dougherty and WD Willis
Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77550-2772.
Sensitization of the responses of dorsal horn neurons to mechanical
stimulation may play a role in the generation of hyperalgesia. Intradermal
injection of capsaicin (CAP) provides a model of experimental hyperalgesia
that possesses a component of allodynia. This hyperalgesia is produced by
chemical stimulation of C-fibers, leading to sensitization of dorsal horn
neurons, including spinothalamic tract (STT) cells. The changes in the
physiological responses of STT neurons following intradermal CAP in monkeys
parallel the acute pain and hyperalgesia produced by intradermal CAP in
humans. The present study addresses the role that excitatory amino acids
(EAAs) may play in the sensitization of STT neurons by intradermal CAP. Our
results show that the background discharge rate and the responses of STT
cells to mechanical stimulation increase following intradermal CAP. In
addition, the responses of the sensitized cells to one or more
iontophoretically released EAA agonists, including NMDA, glutamate,
aspartate, kainate, DL-alpha-amino-3-hydroxy-5-methyl-isoxazoleproprionic
acid, and/or quisqualate, increase following intradermal CAP. It is
proposed that an increase in the responses of STT neurons to EAAs
contributes to the hyperalgesia produced by this noxious chemical stimulus.
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