 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 12, 1538-1547, Copyright © 1992 by Society for Neuroscience
Pre-oligodendrocytes from adult human CNS
RC Armstrong, HH Dorn, CV Kufta, E Friedman and ME Dubois-Dalcq
Laboratory of Viral and Molecular Pathogenesis, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
CNS remyelination and functional recovery often occur after experimental
demyelination in adult rodents. This has been attributed to the ability of
mature oligodendrocytes and/or their precursor cells to divide and
regenerate in response to signals in demyelinating lesions. To determine
whether oligodendrocyte precursor cells exist in the adult human CNS, we
have cultured white matter from patients undergoing partial temporal lobe
resection for intractable epilepsy. These cultures contained a population
of process-bearing cells that expressed antigens recognized by the O4
monoclonal antibody, but these cells did not express galactocerebroside (a
marker for oligodendrocytes), glial fibrillary acidic protein (a marker for
astrocytes), or vimentin. Selective elimination of O4-positive (O4+) cells
by complement-mediated lysis resulted in inhibition of oligodendrocyte
development in vitro. Since O4+ cells have an antigenic phenotype
reminiscent of the rat adult oligodendrocyte-type 2 astrocyte progenitor
and appear to develop into oligodendrocytes rather than type 2 astrocytes
with time in culture, we call them "pre-oligodendrocytes." Neither
pre-oligodendrocytes nor oligodendrocytes incorporated 3H- thymidine in
response to rat astrocyte-conditioned medium, platelet- derived growth
factor, insulin-like growth factor (IGF-1), or basic fibroblast growth
factor (bFGF). However, IGF-1 increased the relative abundance of
oligodendrocytes to pre-oligodendrocytes, while bFGF had the opposite
effect. Cells with the antigenic phenotype of pre- oligodendrocytes were
also identified in tissue prints of adult human white matter. We propose
that, in human demyelinating diseases such as multiple sclerosis,
pre-oligodendrocytes may divide and/or migrate in response to signals
present in demyelinated lesions and thus facilitate remyelination.
This article has been cited by other articles:
|
|
|
|
 
P. He and Y. Shen
Interruption of {beta}-Catenin Signaling Reduces Neurogenesis in Alzheimer's Disease
J. Neurosci.,
May 20, 2009;
29(20):
6545 - 6557.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-T. Lin and Y.-H. Fu
miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination
Dis. Model. Mech.,
March 1, 2009;
2(3-4):
178 - 188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sanai, A. Alvarez-Buylla, and M. S. Berger
Neural Stem Cells and the Origin of Gliomas
N. Engl. J. Med.,
August 25, 2005;
353(8):
811 - 822.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ruffini, N. Arbour, M. Blain, A. Olivier, and J. P. Antel
Distinctive Properties of Human Adult Brain-Derived Myelin Progenitor Cells
Am. J. Pathol.,
December 1, 2004;
165(6):
2167 - 2175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Picard-Riera, L. Decker, C. Delarasse, K. Goude, B. Nait-Oumesmar, R. Liblau, D. Pham-Dinh, and A. B.-V. Evercooren
Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice
PNAS,
October 1, 2002;
99(20):
13211 - 13216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Genoud, C. Lappe-Siefke, S. Goebbels, F. Radtke, M. Aguet, S. S. Scherer, U. Suter, K.-A. Nave, and N. Mantei
Notch1 control of oligodendrocyte differentiation in the spinal cord
J. Cell Biol.,
August 19, 2002;
158(4):
709 - 718.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Chang, W. W. Tourtellotte, R. Rudick, and B. D. Trapp
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
N. Engl. J. Med.,
January 17, 2002;
346(3):
165 - 173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Back, N. L. Luo, N. S. Borenstein, J. M. Levine, J. J. Volpe, and H. C. Kinney
Late Oligodendrocyte Progenitors Coincide with the Developmental Window of Vulnerability for Human Perinatal White Matter Injury
J. Neurosci.,
February 15, 2001;
21(4):
1302 - 1312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Chang, A. Nishiyama, J. Peterson, J. Prineas, and B. D. Trapp
NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions
J. Neurosci.,
September 1, 2000;
20(17):
6404 - 6412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Warrington, K. Asakura, A. J. Bieber, B. Ciric, V. Van Keulen, S. V. Kaveri, R. A. Kyle, L. R. Pease, and M. Rodriguez
Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis
PNAS,
June 6, 2000;
97(12):
6820 - 6825.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Wolswijk
Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis
Brain,
January 1, 2000;
123(1):
105 - 115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. Roy, S. Wang, C. Harrison-Restelli, A. Benraiss, R. A. R. Fraser, M. Gravel, P. E. Braun, and S. A. Goldman
Identification, Isolation, and Promoter-Defined Separation of Mitotic Oligodendrocyte Progenitor Cells from the Adult Human Subcortical White Matter
J. Neurosci.,
November 15, 1999;
19(22):
9986 - 9995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Figarella-Branger, L. Daniel, P. Andre, S. Guia, W. Renaud, G. Monti, E. Vivier, and G. Rougon
The PEN5 Epitope Identifies an Oligodendrocyte Precursor Cell Population and Pilocytic Astrocytomas
Am. J. Pathol.,
October 1, 1999;
155(4):
1261 - 1269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-C. Zhang, B. Ge, and I. D. Duncan
Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity
PNAS,
March 30, 1999;
96(7):
4089 - 4094.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Wrathall, W. Li, and L. D. Hudson
Myelin Gene Expression after Experimental Contusive Spinal Cord Injury
J. Neurosci.,
November 1, 1998;
18(21):
8780 - 8793.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Asakura, D. J. Miller, L. R. Pease, and M. Rodriguez
Targeting of IgMkappa Antibodies to Oligodendrocytes Promotes CNS Remyelination
J. Neurosci.,
October 1, 1998;
18(19):
7700 - 7708.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Shi, A. Marinovich, and B. A. Barres
Purification and Characterization of Adult Oligodendrocyte Precursor Cells from the Rat Optic Nerve
J. Neurosci.,
June 15, 1998;
18(12):
4627 - 4636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-X. Li, A. E Schaffner, M. K Walton, and J. L Barker
Astrocytes regulate developmental changes in the chloride ion gradient of embryonic rat ventral spinal cord neurons in culture
J. Physiol.,
June 15, 1998;
509(3):
847 - 858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Gasque, S. K. Singhrao, J. W. Neal, P. Wang, S. Sayah, M. Fontaine, and B. P. Morgan
The Receptor for Complement Anaphylatoxin C3a Is Expressed by Myeloid Cells and Nonmyeloid Cells in Inflamed Human Central Nervous System: Analysis in Multiple Sclerosis and Bacterial Meningitis
J. Immunol.,
April 1, 1998;
160(7):
3543 - 3554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Wolswijk
Chronic Stage Multiple Sclerosis Lesions Contain a Relatively Quiescent Population of Oligodendrocyte Precursor Cells
J. Neurosci.,
January 15, 1998;
18(2):
601 - 609.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Compston
Remyelination in multiple sclerosis: a challenge for therapy: The 1996 European Charcot Foundation Lecture
Multiple Sclerosis,
April 1, 1997;
3(2):
51 - 70.
[PDF]
|
|
|
|
|
|
|
H. d. F Webster
Growth factors and myelin regeneration in multiple sclerosis
Multiple Sclerosis,
April 1, 1997;
3(2):
113 - 120.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Wolswijk
Oligodendrocyte precursor cells in chronic multiple sclerosis lesions
Multiple Sclerosis,
April 1, 1997;
3(2):
168 - 169.
[PDF]
|
|
|
|
|
|
|
M. Hajihosseini, T. N. Tham, and M. Dubois-Dalcq
Origin of Oligodendrocytes within the Human Spinal Cord
J. Neurosci.,
December 15, 1996;
16(24):
7981 - 7994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Compston
Remyelination of the central nervous system
Multiple Sclerosis,
June 1, 1996;
1(6):
388 - 392.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Q.-Y. Liu, A. E. Schaffner, Y.-X. Li, V. Dunlap, and J. L. Barker
Upregulation of GABAA Current by Astrocytes in Cultured Embryonic Rat Hippocampal Neurons
J. Neurosci.,
May 1, 1996;
16(9):
2912 - 2923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Goldman
Review : Neuronal Precursor Cells and Neurogenesis in the Adult Forebrain
Neuroscientist,
November 1, 1995;
1(6):
338 - 350.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J Zajicek and A Compston
Mechanisms of damage and repair in multiple sclerosis -- a review
Multiple Sclerosis,
June 1, 1995;
1(2):
61 - 72.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K Ono, R Bansal, J Payne, U Rutishauser, and R. Miller
Early development and dispersal of oligodendrocyte precursors in the embryonic chick spinal cord
Development,
January 6, 1995;
121(6):
1743 - 1754.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. W. Levison, C. Chuang, B. J. Abramson, and J. E. Goldman
The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated
Development,
November 1, 1993;
119(3):
611 - 622.
[Abstract]
[PDF]
|
|
|
|
|
