WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience ScienceCareers.org
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pleasure, S. J.
Right arrow Articles by Lee, V. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pleasure, S. J.
Right arrow Articles by Lee, V. M.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 12, 1802-1815, Copyright © 1992 by Society for Neuroscience

ARTICLE

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

SJ Pleasure, C Page and VM Lee
David Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.

NTera 2/cl.D1 (NT2) cells, a human teratocarcinoma cell line, were manipulated following retinoic acid treatment to yield greater than 95% pure cultures of neuronal cells (NT2-N cells). The commitment of NT2-N cells to a stable neuronal phenotype is irreversible as judged by the lack of mitotic activity or phenotypic reversion over a period of 2 months in culture. Furthermore, NT2-N cells express a variety of neuronal markers including many neuronal cytoskeletal proteins, secretory markers, and surface markers. NT2-N cells resemble primary neuronal cultures from rodents morphologically and in density of process outgrowth and, like primary neurons, go on to elaborate processes that differentiate into axons and dendrites. This culture method yields sufficient highly differentiated postmitotic NT2-N cells for both biochemical and molecular biological studies. Indeed, when undifferentiated NT2 cells were stably transfected with a beta- galactosidase (beta-gal) expression plasmid, beta-gal expression was shown to be present in both undifferentiated NT2 and postmitotic NT2-N cells. Thus, the ability to transfect expression plasmids into undifferentiated NT2 cells will allow the introduction of normal and mutant gene products into cells that can then be induced to become stable, postmitotic human neurons. We conclude that NT2 cells and NT2-N cells represent a unique model system for studies of human neurons, and a novel vehicle for the expression of diverse gene products in terminally differentiated polarized neurons.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Lafon, F. Megret, S. G. Meuth, O. Simon, M. L. Velandia Romero, M. Lafage, L. Chen, L. Alexopoulou, R. A. Flavell, C. Prehaud, et al.
Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis
J. Immunol., June 1, 2008; 180(11): 7506 - 7515.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Zhang, Z.-H. Li, M. Q. Zhang, M. S. Katz, and B.-X. Zhang
Heat Shock Protein 90{beta}1 Is Essential for Polyunsaturated Fatty Acid-induced Mitochondrial Ca2+ Efflux
J. Biol. Chem., March 21, 2008; 283(12): 7580 - 7589.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Feldmann, V. Glukmann, E. Medvenev, U. Shpolansky, D. Galili, D. Lichtstein, and H. Rosen
Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis
Am J Physiol Cell Physiol, September 1, 2007; 293(3): C885 - C896.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
C.-G. Liew, J. S. Draper, J. Walsh, H. Moore, and P. W. Andrews
Transient and Stable Transgene Expression in Human Embryonic Stem Cells
Stem Cells, June 1, 2007; 25(6): 1521 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
R. A. Pon, N. J. Biggs, and H. J. Jennings
Polysialic acid bioengineering of neuronal cells by N-acyl sialic acid precursor treatment
Glycobiology, March 1, 2007; 17(3): 249 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
K. M. R. Bhat, N. Maddodi, C. Shashikant, and V. Setaluri
Transcriptional regulation of human MAP2 gene in melanoma: role of neuronal bHLH factors and Notch1 signaling
Nucleic Acids Res., August 11, 2006; 34(13): 3819 - 3832.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
L. J. Frassetto, C. R. Schlieve, C. J. Lieven, A. A. Utter, M. V. Jones, N. Agarwal, and L. A. Levin
Kinase-Dependent Differentiation of a Retinal Ganglion Cell Precursor
Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 427 - 438.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Lafon, C. Prehaud, F. Megret, M. Lafage, G. Mouillot, M. Roa, P. Moreau, N. Rouas-Freiss, and E. D. Carosella
Modulation of HLA-G Expression in Human Neural Cells after Neurotropic Viral Infections
J. Virol., December 15, 2005; 79(24): 15226 - 15237.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
F. Gabanella, C. Carissimi, A. Usiello, and L. Pellizzoni
The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation
Hum. Mol. Genet., December 1, 2005; 14(23): 3629 - 3642.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Prehaud, F. Megret, M. Lafage, and M. Lafon
Virus Infection Switches TLR-3-Positive Human Neurons To Become Strong Producers of Beta Interferon
J. Virol., October 15, 2005; 79(20): 12893 - 12904.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Ludemann, A. Clement, V. H. Hans, J. Leschik, C. Behl, and R. Brandt
O-Glycosylation of the Tail Domain of Neurofilament Protein M in Human Neurons and in Spinal Cord Tissue of a Rat Model of Amyotrophic Lateral Sclerosis (ALS)
J. Biol. Chem., September 9, 2005; 280(36): 31648 - 31658.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
J.-P. Lai, S. D. Douglas, Y.-J. Wang, and W.-Z. Ho
Real-Time Reverse Transcription-PCR Quantitation of Substance P Receptor (NK-1R) mRNA
Clin. Vaccine Immunol., April 1, 2005; 12(4): 537 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Daniel, E. Marusich, E. Argyris, R. Y. Zhao, A. M. Skalka, and R. J. Pomerantz
Caffeine Inhibits Human Immunodeficiency Virus Type 1 Transduction of Nondividing Cells
J. Virol., February 15, 2005; 79(4): 2058 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
L. Ricci-Vitiani, F. Pedini, C. Mollinari, G. Condorelli, D. Bonci, A. Bez, A. Colombo, E. Parati, C. Peschle, and R. De Maria
Absence of Caspase 8 and High Expression of PED Protect Primitive Neural Cells from Cell Death
J. Exp. Med., November 15, 2004; 200(10): 1257 - 1266.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. D. Little, M. E. Hemler, and C. S. Stipp
Dynamic Regulation of a GPCR-Tetraspanin-G Protein Complex on Intact Cells: Central Role of CD81 in Facilitating GPR56-G{alpha}q/11 Association
Mol. Biol. Cell, May 1, 2004; 15(5): 2375 - 2387.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Rosen, V. Glukhman, T. Feldmann, E. Fridman, and D. Lichtstein
Cardiac Steroids Induce Changes in Recycling of the Plasma Membrane in Human NT2 Cells
Mol. Biol. Cell, March 1, 2004; 15(3): 1044 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. M. Harris, I. Tesseur, W. J. Brecht, Q. Xu, K. Mullendorff, S. Chang, T. Wyss-Coray, R. W. Mahley, and Y. Huang
Astroglial Regulation of Apolipoprotein E Expression in Neuronal Cells: IMPLICATIONS FOR ALZHEIMER'S DISEASE
J. Biol. Chem., January 30, 2004; 279(5): 3862 - 3868.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Piontek and R. Brandt
Differential and Regulated Binding of cAMP-dependent Protein Kinase and Protein Kinase C Isoenzymes to Gravin in Human Model Neurons: EVIDENCE THAT GRAVIN PROVIDES A DYNAMIC PLATFORM FOR THE LOCALIZATION OF KINASES DURING NEURONAL DEVELOPMENT
J. Biol. Chem., October 3, 2003; 278(40): 38970 - 38979.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Li, T. Zhang, S. D. Douglas, J.-P. Lai, W.-D. Xiao, D. E. Pleasure, and W.-Z. Ho
Morphine Enhances Hepatitis C Virus (HCV) Replicon Expression
Am. J. Pathol., September 1, 2003; 163(3): 1167 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Fang, J. Chartier, C. Sodja, A. Desbois, M. Ribecco-Lutkiewicz, P. R. Walker, and M. Sikorska
Transcriptional Activation of the Human Brain-derived Neurotrophic Factor Gene Promoter III by Dopamine Signaling in NT2/N Neurons
J. Biol. Chem., July 11, 2003; 278(29): 26401 - 26409.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
S. Alexander Przyborski, S. Smith, and A. Wood
Transcriptional Profiling of Neuronal Differentiation by Human Embryonal Carcinoma Stem Cells In Vitro
Stem Cells, July 1, 2003; 21(4): 459 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Pigino, G. Morfini, A. Pelsman, M. P. Mattson, S. T. Brady, and J. Busciglio
Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport
J. Neurosci., June 1, 2003; 23(11): 4499 - 4508.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. H. Chalasani, F. Baribaud, C. M. Coughlan, M. J. Sunshine, V. M. Y. Lee, R. W. Doms, D. R. Littman, and J. A. Raper
The Chemokine Stromal Cell-Derived Factor-1 Promotes the Survival of Embryonic Retinal Ganglion Cells
J. Neurosci., June 1, 2003; 23(11): 4601 - 4612.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
R. Stewart, V. B. Christie, and S. A. Przyborski
Manipulation of Human Pluripotent Embryonal Carcinoma Stem Cells and the Development of Neural Subtypes
Stem Cells, May 1, 2003; 21(3): 248 - 256.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
X. Yu, J. J. Shacka, J. B. Eells, C. Suarez-Quian, R. M. Przygodzki, B. Beleslin-Cokic, C.-S. Lin, V. M. Nikodem, B. Hempstead, K. C. Flanders, et al.
Erythropoietin receptor signalling is required for normal brain development
Development, March 3, 2003; 129(2): 505 - 516.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. B. Lee, D. M. Skovronsky, F. Abtahian, R. W. Doms, and V. M.-Y. Lee
Secretion and Intracellular Generation of Truncated Abeta in beta -Site Amyloid-beta Precursor Protein-cleaving Enzyme Expressing Human Neurons
J. Biol. Chem., February 7, 2003; 278(7): 4458 - 4466.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Fath, J. Eidenmuller, and R. Brandt
Tau-Mediated Cytotoxicity in a Pseudohyperphosphorylation Model of Alzheimer's Disease
J. Neurosci., November 15, 2002; 22(22): 9733 - 9741.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
W. Chen, J. Sulcove, I. Frank, S. Jaffer, H. Ozdener, and D. L. Kolson
Development of a Human Neuronal Cell Model for Human Immunodeficiency Virus (HIV)-Infected Macrophage-Induced Neurotoxicity: Apoptosis Induced by HIV Type 1 Primary Isolates and Evidence for Involvement of the Bcl-2/Bcl-xL-Sensitive Intrinsic Apoptosis Pathway
J. Virol., August 12, 2002; 76(18): 9407 - 9419.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. J. Solecki, M. Gromeier, S. Mueller, G. Bernhardt, and E. Wimmer
Expression of the Human Poliovirus Receptor/CD155 Gene Is Activated by Sonic Hedgehog
J. Biol. Chem., July 5, 2002; 277(28): 25697 - 25702.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Yang, K. Lindholm, Y. Konishi, R. Li, and Y. Shen
Target Depletion of Distinct Tumor Necrosis Factor Receptor Subtypes Reveals Hippocampal Neuron Death and Survival through Different Signal Transduction Pathways
J. Neurosci., April 15, 2002; 22(8): 3025 - 3032.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. T. Nelson, D. Kondziolka, L. Wechsler, S. Goldstein, J. Gebel, S. DeCesare, E. M. Elder, P. J. Zhang, A. Jacobs, M. McGrogan, et al.
Clonal Human (hNT) Neuron Grafts for Stroke Therapy : Neuropathology in a Patient 27 Months after Implantation
Am. J. Pathol., April 1, 2002; 160(4): 1201 - 1206.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. W. Charter, L. K. Mahal, D. E. Koshland Jr., and C. R. Bertozzi
Differential Effects of Unnatural Sialic Acids on the Polysialylation of the Neural Cell Adhesion Molecule and Neuronal Behavior
J. Biol. Chem., March 8, 2002; 277(11): 9255 - 9261.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. Wong, L. Cavelier, H. E. Collins-Schramm, M. F. Seldin, M. McGrogan, M.-L. Savontaus, and G. A. Cortopassi
Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells
Hum. Mol. Genet., February 1, 2002; 11(4): 431 - 438.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
J.-P. Lai, S. D. Douglas, F. Shaheen, D. E. Pleasure, and W.-Z. Ho
Quantification of Substance P mRNA in Human Immune Cells by Real-Time Reverse Transcriptase PCR Assay
Clin. Vaccine Immunol., January 1, 2002; 9(1): 138 - 143.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L. K. Mahal, N. W. Charter, K. Angata, M. Fukuda, D. E. Koshland Jr., and C. R. Bertozzi
A Small-Molecule Modulator of Poly-alpha 2,8-Sialic Acid Expression on Cultured Neurons and Tumor Cells
Science, October 12, 2001; 294(5541): 380 - 381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Kyin, Y. Hua, M. Baybis, B. Scheithauer, D. Kolson, E. Uhlmann, D. Gutmann, and P. B. Crino
Differential Cellular Expression of Neurotrophins in Cortical Tubers of the Tuberous Sclerosis Complex
Am. J. Pathol., October 1, 2001; 159(4): 1541 - 1554.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Huang, X. Q. Liu, T. Wyss-Coray, W. J. Brecht, D. A. Sanan, and R. W. Mahley
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
PNAS, July 5, 2001; (2001) 151254698.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
W.-L. Hsu and R. D. Everett
Human Neuron-Committed Teratocarcinoma NT2 Cell Line Has Abnormal ND10 Structures and Is Poorly Infected by Herpes Simplex Virus Type 1
J. Virol., April 15, 2001; 75(8): 3819 - 3831.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
J. A. Wolf, P. K. Stys, T. Lusardi, D. Meaney, and D. H. Smith
Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels
J. Neurosci., March 15, 2001; 21(6): 1923 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. R. Neelands, A. P. J. King, and R. L. Macdonald
Functional Expression of L-, N-, P/Q-, and R-Type Calcium Channels in the Human NT2-N Cell Line
J Neurophysiol, December 1, 2000; 84(6): 2933 - 2944.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. A. Patel, M. Mukhtar, and R. J. Pomerantz
Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis in Human Neuronal Cells
J. Virol., October 15, 2000; 74(20): 9717 - 9726.
[Abstract] [Full Text]

Home page
 Cell Growth Differ.Home page
G. Baldassarre, A. Boccia, P. Bruni, C. Sandomenico, M. V. Barone, S. Pepe, T. Angrisano, B. Belletti, M. L. Motti, A. Fusco, et al.
Retinoic Acid Induces Neuronal Differentiation of Embryonal Carcinoma Cells by Reducing Proteasome-dependent Proteolysis of the Cyclin-dependent Inhibitor p27
Cell Growth Differ., October 1, 2000; 11(10): 517 - 526.
[Abstract] [Full Text]

Home page
 GlycobiologyHome page
N. W. Charter, L. K. Mahal, D. E. Koshland Jr., and C. R. Bertozzi
Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells
Glycobiology, October 1, 2000; 10(10): 1049 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Stipp and M. Hemler
Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth
J. Cell Sci., January 6, 2000; 113(11): 1871 - 1882.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
M. Mizuguchi, J. Qin, M. Yamada, K. Ikeda, and S. Takashima
High Expression of Doublecortin and KIAA0369 Protein in Fetal Brain Suggests Their Specific Role in Neuronal Migration
Am. J. Pathol., November 1, 1999; 155(5): 1713 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Uetsuki, K. Takemoto, I. Nishimura, M. Okamoto, M. Niinobe, T. Momoi, M. Miura, and K. Yoshikawa
Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein
J. Neurosci., August 15, 1999; 19(16): 6955 - 6964.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. R. Neelands, J. Zhang, and R. L. Macdonald
GABAA Receptors Expressed in Undifferentiated Human Teratocarcinoma NT2 Cells Differ from Those Expressed by Differentiated NT2-N Cells
J. Neurosci., August 15, 1999; 19(16): 7057 - 7065.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. H. Smith, J. A. Wolf, T. A. Lusardi, V. M.-Y. Lee, and D. F. Meaney
High Tolerance and Delayed Elastic Response of Cultured Axons to Dynamic Stretch Injury
J. Neurosci., June 1, 1999; 19(11): 4263 - 4269.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Martin-Villalba, I. Herr, I. Jeremias, M. Hahne, R. Brandt, J. Vogel, J. Schenkel, T. Herdegen, and K.-M. Debatin
CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons
J. Neurosci., May 15, 1999; 19(10): 3809 - 3817.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Lawinger, L. Rastelli, Z. Zhao, and S. Majumder
Lack of Enhancer Function in Mammals Is Unique to Oocytes and Fertilized Eggs
J. Biol. Chem., March 19, 1999; 274(12): 8002 - 8011.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. Antic, N. Lu, and J. D. Keene
ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells
Genes & Dev., February 15, 1999; 13(4): 449 - 461.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
C.-S. Hong, L. Caromile, Y. Nomata, H. Mori, D. E. Bredesen, and E. H. Koo
Contrasting Role of Presenilin-1 and Presenilin-2 in Neuronal Differentiation In Vitro
J. Neurosci., January 15, 1999; 19(2): 637 - 643.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. L. Edinger, T. L. Hoffman, M. Sharron, B. Lee, Y. Yi, W. Choe, D. L. Kolson, B. Mitrovic, Y. Zhou, D. Faulds, et al.
An Orphan Seven-Transmembrane Domain Receptor Expressed Widely in the Brain Functions as a Coreceptor for Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
J. Virol., October 1, 1998; 72(10): 7934 - 7940.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. Poeschla, J. Gilbert, X. Li, S. Huang, A. Ho, and F. Wong-Staal
Identification of a Human Immunodeficiency Virus Type 2 (HIV-2) Encapsidation Determinant and Transduction of Nondividing Human Cells by HIV-2-Based Lentivirus Vectors
J. Virol., August 1, 1998; 72(8): 6527 - 6536.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. R. Neelands, L. J. Greenfield Jr, J. Zhang, R. S. Turner, and R. L. Macdonald
GABAA Receptor Pharmacology and Subtype mRNA Expression in Human Neuronal NT2-N Cells
J. Neurosci., July 1, 1998; 18(13): 4993 - 5007.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. McQuaid, S. Campbell, I. J. C. Wallace, J. Kirk, and S. L. Cosby
Measles Virus Infection and Replication in Undifferentiated and Differentiated Human Neuronal Cells in Culture
J. Virol., June 1, 1998; 72(6): 5245 - 5250.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Jolly-Tornetta, Z.-y. Gao, V. M.-Y. Lee, and B. A. Wolf
Regulation of Amyloid Precursor Protein Secretion by Glutamate Receptors in Human Ntera 2 Neurons (NT2N)
J. Biol. Chem., May 29, 1998; 273(22): 14015 - 14021.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
D. M. Skovronsky, R. W. Doms, and V. M.-Y. Lee
Detection of a Novel Intraneuronal Pool of Insoluble Amyloid beta  Protein that Accumulates with Time in Culture
J. Cell Biol., May 18, 1998; 141(4): 1031 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. S. Forman, D. G. Cook, S. Leight, R. W. Doms, and V. M.-Y. Lee
Differential Effects of the Swedish Mutant Amyloid Precursor Protein on beta -Amyloid Accumulation and Secretion in Neurons and Nonneuronal Cells
J. Biol. Chem., December 19, 1997; 272(51): 32247 - 32253.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Hong, D. C. R. Chen, P. S. Klein, and V. M.-Y. Lee
Lithium Reduces Tau Phosphorylation by Inhibition of Glyc