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Journal of Neuroscience, Vol 12, 1826-1838, Copyright © 1992 by Society for Neuroscience
A critical period for experience-dependent synaptic plasticity in rat barrel cortex
K Fox
Section of Neurobiology, Brown University, Providence, Rhode Island 02912.
Recordings were made from neurons in layers II, III, and IV of rat barrel
cortex. The animals were raised either from the day of birth (P0) or from
P2, P4, or P7 with just the D1 vibrissa protruding on one side of the face
and the contralateral side intact. Follicles were not ablated, but
vibrissae were carefully removed by applying steady tension to the base of
each vibrissa. Deprivation was continued until the day of recording
(P30-P90), though in most cases vibrissae were allowed to regrow for 4-7 d
prior to recording. The area of cortex driven by stimulating the spared D1
vibrissa was found to be enlarged in uni-vibrissae animals, but the
characteristic anatomical map of the barrel field, defined by cytochrome
oxidase staining, retained its normal form. In animals deprived from P0,
layer IV cells outside the D1 barrel responded with short latencies (5-10
msec) to D1 stimulation, a condition never observed in normally reared
animals. Short-latency responses to stimulation of regrown, deprived
vibrissae were still present in layer IV despite the deprivation.
Plasticity decreased rapidly in layer IV between P0 and P4 as judged by two
measures: first, the percentage of cells in neighboring barrels that showed
short- latency responses to D1 fell from 30% in P0 deprived animals to 18%
in P2 and 13% in P4 deprived animals. Second, the percentage of cells in
barrels surrounding D1 with larger responses to D1 stimulation than to
stimulation of their anatomically related vibrissa also fell from 37% in P0
to 23% in P2 and 12% in P4 deprived animals. The percentage of "shifted
cells" showed no further reduction in P7 deprived animals (14%). Plasticity
in layers II and III showed little sign of decreasing between P2 and P7
after an initial drop between P0 and P2. Therefore, deprivation started at
P4 and P7 had a far greater effect on layers II and III than on layer IV.
In animals deprived from P4 onward, not only were responses to D1
stimulation greater in barrels neighboring D1 (in layers II/III), but
responses were smaller to principal vibrissa stimulation. This suggests
increased lateral transmission from the "experienced" barrel and a failure
of vertical transmission within the "deprived" barrels. These results show
that changes in the balance of experience acquired through vibrissae can
affect development of connectivity in the barrel cortex. The main locus of
plasticity is cortical when deprivations are started at P4 and
beyond.(ABSTRACT TRUNCATED AT 400 WORDS)
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