 |
 Previous Article
Journal of Neuroscience, Vol 12, 2000-2006, Copyright © 1992 by Society for Neuroscience
5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons
SW Johnson, NB Mercuri and RA North
Vollum Institute, Oregon Health Sciences University, Portland 97201.
Intracellular recordings were made from presumed dopamine-containing
neurons in slices cut from the midbrain of the rat. Focal electrical
stimulation produced a hyperpolarizing synaptic potential that was reduced
by 75-95% by the GABAB-receptor antagonist 2-hydroxysaclofen (300 microM).
5-HT (3-100 microM) reduced the amplitude of the GABAB synaptic potential
by 20-74%, with a 50% reduction at 10 microM, but did not reduce the
amplitude of synaptic potentials mediated by GABAA receptors. 5-HT acted
presynaptically because hyperpolarizations produced by exogenously
administered GABA (1 mM) in picrotoxin (100 microM) were not affected by
5-HT (30 microM). (+/-)-Cyanopindolol (100 nM), a 5-HT1B antagonist,
blocked the effect of 5-HT (10 microM); spiperone (1 microM), which is an
antagonist at 5-HT1A and 5-HT2 receptors, had no effect. The amplitude of
the GABAB synaptic potential was reduced by the 5-HT1B receptor agonists
1-[3-(trifluoromethyl)- phenyl]-piperazine (300 nM) and
7-trifluoromethyl-4-(4-methyl-1- piperazinyl)-pyrrolo[1,2-a]quinoxaline (1
microM), but not by the 5- HT1A agonist
N,N-dipropyl-5-carboxamidotryptamine (1 microM) or the 5- HT2 agonist
(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (10 microM). We
conclude that 5-HT activates presynaptic 5-HT1B receptors that inhibit the
release of GABA onto GABAB but not GABAA receptors.
This article has been cited by other articles:
|
|
|
|
 
I. Putzier, P. H. M. Kullmann, J. P. Horn, and E. S. Levitan
Dopamine Neuron Responses Depend Exponentially on Pacemaker Interval
J Neurophysiol,
February 1, 2009;
101(2):
926 - 933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Hurley, J. A. Tracy, and A. Bohorquez
Serotonin 1B Receptor Modulates Frequency Response Curves and Spectral Integration in the Inferior Colliculus by Reducing GABAergic Inhibition
J Neurophysiol,
September 1, 2008;
100(3):
1656 - 1667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rav-Acha, H. Bergman, and Y. Yarom
Pre- and Postsynaptic Serotoninergic Excitation of Globus Pallidus Neurons
J Neurophysiol,
August 1, 2008;
100(2):
1053 - 1066.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kaneda, P. Phongphanphanee, T. Katoh, K. Isa, Y. Yanagawa, K. Obata, and T. Isa
Regulation of Burst Activity through Presynaptic and Postsynaptic GABAB Receptors in Mouse Superior Colliculus
J. Neurosci.,
January 23, 2008;
28(4):
816 - 827.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. B. Fink and M. Gothert
5-HT Receptor Regulation of Neurotransmitter Release
Pharmacol. Rev.,
December 1, 2007;
59(4):
360 - 417.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Hnasko, B. N. Sotak, and R. D. Palmiter
Cocaine-Conditioned Place Preference by Dopamine-Deficient Mice Is Mediated by Serotonin
J. Neurosci.,
November 14, 2007;
27(46):
12484 - 12488.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. P. Ford, G. P. Mark, and J. T. Williams
Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location.
J. Neurosci.,
March 8, 2006;
26(10):
2788 - 2797.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kaneda and H. Kita
Synaptically Released GABA Activates Both Pre- and Postsynaptic GABAB Receptors in the Rat Globus Pallidus
J Neurophysiol,
August 1, 2005;
94(2):
1104 - 1114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Bramley, P. J. Sollars, G. E. Pickard, and F. E. Dudek
5-HT1B Receptor-Mediated Presynaptic Inhibition of GABA Release in the Suprachiasmatic Nucleus
J Neurophysiol,
June 1, 2005;
93(6):
3157 - 3164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Federici, R. Geracitano, A. Tozzi, P. Longone, S. Di Angelantonio, C. P. Bengtson, G. Bernardi, and N. B. Mercuri
Trace Amines Depress GABAB Response in Dopaminergic Neurons by Inhibiting G-{beta}{gamma}-Gated Inwardly Rectifying Potassium Channels
Mol. Pharmacol.,
April 1, 2005;
67(4):
1283 - 1290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. O'Dell and L. H. Parsons
Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels
J. Pharmacol. Exp. Ther.,
November 1, 2004;
311(2):
711 - 719.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Neumaier, E. S. Vincow, A. Arvanitogiannis, R. A. Wise, and W. A. Carlezon Jr
Elevated Expression of 5-HT1B Receptors in Nucleus Accumbens Efferents Sensitizes Animals to Cocaine
J. Neurosci.,
December 15, 2002;
22(24):
10856 - 10863.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Rocha, E. H. Goulding, L. E. O'Dell, A. N. Mead, N. G. Coufal, L. H. Parsons, and L. H. Tecott
Enhanced Locomotor, Reinforcing, and Neurochemical Effects of Cocaine in Serotonin 5-Hydroxytryptamine 2C Receptor Mutant Mice
J. Neurosci.,
November 15, 2002;
22(22):
10039 - 10045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Federici, S. Natoli, G. Bernardi, and N. B Mercuri
Dopamine selectively reduces GABAB transmission onto dopaminergic neurones by an unconventional presynaptic action
J. Physiol.,
April 1, 2002;
540(1):
119 - 128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Bankson and K. A. Cunningham
3,4-Methylenedioxymethamphetamine (MDMA) as a Unique Model of Serotonin Receptor Function and Serotonin-Dopamine Interactions
J. Pharmacol. Exp. Ther.,
June 1, 2001;
297(3):
846 - 852.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. Morikawa, O. J. Manzoni, J. C. Crabbe, and J. T. Williams
Regulation of Central Synaptic Transmission by 5-HT1B Auto- and Heteroreceptors
Mol. Pharmacol.,
April 13, 2001;
58(6):
1271 - 1278.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. T. Williams, M. J. Christie, and O. Manzoni
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Physiol Rev,
January 1, 2001;
81(1):
299 - 343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. Hoffman and C. R. Lupica
Mechanisms of Cannabinoid Inhibition of GABAA Synaptic Transmission in the Hippocampus
J. Neurosci.,
April 1, 2000;
20(7):
2470 - 2479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Fiorillo and J. T. Williams
Selective Inhibition by Adenosine of mGluR IPSPs in Dopamine Neurons After Cocaine Treatment
J Neurophysiol,
March 1, 2000;
83(3):
1307 - 1314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Millan, F. Lejeune, and A. Gobert
Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents
J Psychopharmacol,
March 1, 2000;
14(2):
114 - 138.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Flett and C. S. Colwell
Serotonin Modulation of Calcium Transients in Cells in the Suprachiasmatic Nucleus
J Biol Rhythms,
October 1, 1999;
14(5):
354 - 363.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. C. McCreary, M. G. Bankson, and K. A. Cunningham
Pharmacological Studies of the Acute and Chronic Effects of (+)-3,4-Methylenedioxymethamphetamine on Locomotor Activity: Role of 5-Hydroxytryptamine1A and 5-Hydroxytryptamine1B/1D Receptors
J. Pharmacol. Exp. Ther.,
September 1, 1999;
290(3):
965 - 973.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
O. J. Manzoni and J. T. Williams
Presynaptic Regulation of Glutamate Release in the Ventral Tegmental Area During Morphine Withdrawal
J. Neurosci.,
August 1, 1999;
19(15):
6629 - 6636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Rainnie
Serotonergic Modulation of Neurotransmission in the Rat Basolateral Amygdala
J Neurophysiol,
July 1, 1999;
82(1):
69 - 85.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Pickard, B. N. Smith, M. Belenky, M. A. Rea, F. E. Dudek, and P. J. Sollars
5-HT1B Receptor-Mediated Presynaptic Inhibition of Retinal Input to the Suprachiasmatic Nucleus
J. Neurosci.,
May 15, 1999;
19(10):
4034 - 4045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Shoji, J. Delfs, and J. T. Williams
Presynaptic Inhibition of GABAB-Mediated Synaptic Potentials in the Ventral Tegmental Area during Morphine Withdrawal
J. Neurosci.,
March 15, 1999;
19(6):
2347 - 2355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Parsons, F. Weiss, and G. F. Koob
Serotonin1B Receptor Stimulation Enhances Cocaine Reinforcement
J. Neurosci.,
December 1, 1998;
18(23):
10078 - 10089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Madden and S. W. Johnson
Gamma-Hydroxybutyrate is a GABAB Receptor Agonist that Increases a Potassium Conductance in Rat Ventral Tegmental Dopamine Neurons
J. Pharmacol. Exp. Ther.,
October 1, 1998;
287(1):
261 - 265.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. J. Lucas, A. Yamamoto, K. Scearce-Levie, F. Saudou, and R. Hen
Absence of Fenfluramine-Induced Anorexia and Reduced c-fos Induction in the Hypothalamus and Central Amygdaloid Complex of Serotonin 1B Receptor Knock-Out Mice
J. Neurosci.,
July 15, 1998;
18(14):
5537 - 5544.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Radnikow and U. Misgeld
Dopamine D1 Receptors Facilitate GABAA Synaptic Currents in the Rat Substantia Nigra Pars Reticulata
J. Neurosci.,
March 15, 1998;
18(6):
2009 - 2016.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Lucas, L. Segu, and R. Hen
5-Hydroxytryptamine1B Receptors Modulate the Effect of Cocaine on c-fos Expression: Converging Evidence Using 5-Hydroxytryptamine1B Knockout Mice and the 5-Hydroxytryptamine1B/1D Antagonist GR127935
Mol. Pharmacol.,
May 1, 1997;
51(5):
755 - 763.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. El Manira, W. Zhang, E. Svensson, and N. Bussieres
5-HT Inhibits Calcium Current and Synaptic Transmission from Sensory Neurons in Lamprey
J. Neurosci.,
March 1, 1997;
17(5):
1786 - 1794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bonci and J. T. Williams
Increased Probability of GABA Release during Withdrawal from Morphine
J. Neurosci.,
January 15, 1997;
17(2):
796 - 803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Pickard, E. T. Weber, P. A. Scott, A. F. Riberdy, and M. A. Rea
5HT1B Receptor Agonists Inhibit Light-Induced Phase Shifts of Behavioral Circadian Rhythms and Expression of the Immediate-Early Gene c-fos in the Suprachiasmatic Nucleus
J. Neurosci.,
December 15, 1996;
16(24):
8208 - 8220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. M. Stanford and M. G. Lacey
Differential Actions of Serotonin, Mediated by 5-HT1B and 5-HT2C Receptors, on GABA-Mediated Synaptic Input to Rat Substantia Nigra Pars Reticulata Neurons In Vitro
J. Neurosci.,
December 1, 1996;
16(23):
7566 - 7573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Federici, S. Natoli, G. Bernardi, and N. B Mercuri
Dopamine selectively reduces GABAB transmission onto dopaminergic neurones by an unconventional presynaptic action
J. Physiol.,
April 1, 2002;
540(1):
119 - 128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
