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Journal of Neuroscience, Vol 12, 2177-2185, Copyright © 1992 by Society for Neuroscience

ARTICLE

SAG: a Schwann cell membrane glycoprotein

ME Dieperink, A O'Neill, G Magnoni, RL Wollmann, RL Heinrikson, HA Zucher-Neely and K Stefansson
Department of Neurology, University of Chicago, Illinois 60637.

We report on characterization of a 170,000 Da glycoprotein found exclusively in the PNS. We refer to this protein as the Schwann cell membrane glycoprotein (SAG). SAG contains the HNK-1 carbohydrate, which is considered by some to be a marker of adhesion molecules. Its N- terminal sequence is not similar to previously known polypeptide sequences. SAG is found exclusively in the PNS, is present in rat sciatic nerve prior to myelination, and is in both myelinating and nonmyelinating Schwann cells. Tumors of Schwann cell lineage express SAG where axons are present (neurofibromas) but do not in the absence of axons (schwannomas). Schwannoma cells in culture do not express SAG even when exposed to forskolin, an activator of adenylate cyclase. However, schwannoma cells grown in the presence of a neuronal cell line (PC12) express SAG.

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