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Journal of Neuroscience, Vol 12, 2251-2258, Copyright © 1992 by Society for Neuroscience
Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract
SR Glaum and RJ Miller
Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637.
Following microinjection into the nucleus tractus solitarius (NTS), the
effects of glutamate on the baroreceptor reflex are poorly antagonized by
kynurenic acid and DL-2-amino-5-phosphonovaleric acid, suggesting the
possible involvement of metabotropic glutamate receptors in this response.
The metabotropic glutamate receptor agonist 1S,3R-1-
aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) depolarized neurons
located medial to the tractus solitarius (TS) at the level of the area
postrema in coronal sections of the rat NTS. This effect was mimicked by
glutamate and was not blocked by antagonists at alpha-amino-
3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA)/kainate or NMDA
receptors. 1S,3R-ACPD also produced an inward current under voltage clamp
that was not accompanied by a rise in [Ca2+]i, monitored with the
Ca(2+)-sensitive dye fura-2. Conversely, the muscarinic agonist carbachol
produced an outward current and a rise in [Ca2+]i. 1S,3R-ACPD reduced both
the excitatory and the inhibitory postsynaptic current resulting from
single electrical stimuli in the region of the TS. High- frequency
stimulation of the TS produced an inward current in the presence of
AMPA/kainate and NMDA receptor blockers. This current had similar
properties to that produced by 1S,3R-ACPD. Thus, metabotropic glutamate
receptors may mediate a component of excitatory transmission in the NTS.
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