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Journal of Neuroscience, Vol 12, 2918-2947, Copyright © 1992 by Society for Neuroscience
Neurophysiological correlates of hand preference in primary motor cortex of adult squirrel monkeys
RJ Nudo, WM Jenkins, MM Merzenich, T Prejean and R Grenda
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77030.
Variability in the functional topography of area 4 was examined in adult
squirrel monkeys. Conventional intracortical microstimulation techniques
were used to derive detailed maps (250 microns interpenetration distances)
of distal forelimb movement representations in both hemispheres of six
monkeys. Spatial features of these representational maps were then compared
to the hand preferred by the individual animals during a motor task
requiring skilled digit use. Beyond a few broad generalizations common to
all area 4 motor maps, the local mosaic-like topography of individual
distal forelimb representations was highly idiosyncratic. Using statistical
procedures to determine the independent contributions of individual, side,
and movement category to the total variation in motor maps, the results
demonstrate statistically significant variation in representational
topography among individuals as well as between hemispheres of the same
individuals. In the dominant hemisphere (i.e., the hemisphere opposite the
preferred hand), the distal forelimb representations generally were greater
in number and larger in total area, and displayed a longer total boundary
length and a greater index of spatial complexity. Because of the direct
relationship between interhemispheric asymmetry and behavioral asymmetry,
these studies suggest that a large source of variability found in the
topography of motor maps in this and other studies derives from differences
in the way particular movements and/or movement combinations are performed
by individual animals.
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