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Journal of Neuroscience, Vol 12, 3025-3041, Copyright © 1992 by Society for Neuroscience
The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli
PM Dougherty, J Palecek, V Paleckova, LS Sorkin and WD Willis
Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77555-0843.
The role of excitatory amino acids (EAAs) in the excitation of monkey
spinothalamic tract (STT) neurons following activation of cutaneous primary
afferent fibers by noxious and non-noxious stimuli was investigated. The
responses of STT neurons to either NMDA or non-NMDA EAA ligands were
blocked by infusion of specific antagonists through a microdialysis fiber
into the region surrounding the cells. Our results show that blockade of
non-NMDA receptors results in a nearly complete elimination of the
responses of STT neurons to all stimuli. Blockade of NMDA receptors results
in an attenuation of the responses to noxious stimuli but, in addition,
prevents the development of the sensitization of STT neurons that is often
observed after intradermal injection of capsaicin. These observations
further support a role of EAAs in the transmission of sensory information
from primary afferent fibers to dorsal horn neurons and a role for NMDA
receptors in the generation of hyperalgesia.
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