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Journal of Neuroscience, Vol 12, 3107-3114, Copyright © 1992 by Society for Neuroscience
Polysialic acid is required for optimal growth of axons on a neuronal substrate
H Zhang, RH Miller and U Rutishauser
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4901.
Formation of axonal pathways involves a variety of molecules that influence
cell-cell interactions. The polysialic acid (PSA) moiety of the neural cell
adhesion molecule (NCAM) is present on neuronal surfaces during process
outgrowth. Our studies reveal that the removal of PSA causes a decrease in
the rate of elongation of retinal cell processes on a substrate of neuronal
membranes derived from chick tectum. This effect was partially reversed by
antibodies against the L1 adhesion molecule, but not by antibodies against
NCAM, N-cadherin, or beta 1-integrins. This predominant effect of PSA on L1
was also observed in short-term, cell-cell adhesion assays, suggesting that
PSA promotes optimal outgrowth on neuronal substrates by limiting the
consequences of L1-mediated adhesion.
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