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Journal of Neuroscience, Vol 12, 3217-3225, Copyright © 1992 by Society for Neuroscience
Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons
M Wong and RL Moss
Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235-9040.
The ovarian steroids exert both long-term and short-term actions on neurons
involving different cellular mechanisms. We have investigated the long-term
and short-term effects of estrogen on the electrophysiological properties
of CA1 neurons utilizing intracellular recordings in hippocampal slices
prepared from ovariectomized female rats. An in vivo estrogen-priming
paradigm was used to examine long- term genomic actions of estrogen.
Subcutaneous estrogen injections 2 d prior to recording had no effect on
the intrinsic membrane properties of CA1 neurons, but increased synaptic
excitability by prolonging the EPSP and inducing repetitive firing in
response to Schaffer collateral stimulation. Short-term effects of estrogen
that presumedly involve direct membrane interactions were tested by
application of steroids directly to the slice. Superfusion of 17
beta-estradiol, but not 17 alpha-estradiol, caused a rapid and reversible
increase in the amplitude of the Schaffer collateral-activated EPSP. This
potentiation of the EPSP by 17 beta-estradiol still occurred in the
presence of the NMDA antagonist 2-amino-5-phosphonovalerate, but was
blocked by the non- NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione.
Depolarizing responses to iontophoretic pulses of exogenous glutamate were
also potentiated by 17 beta-estradiol, suggesting a post-synaptic site of
action. In addition, 17 beta-estradiol potentiated the responses to
alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid, kainate, and
quisqualate, but not NMDA, further implicating non-NMDA receptors in the
short-term action of estrogen. In contrast, 17 beta-estradiol had no effect
on responses to exogenous GABA or on the Schaffer collateral- induced late
IPSP.(ABSTRACT TRUNCATED AT 250 WORDS)
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