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Journal of Neuroscience, Vol 12, 3226-3240, Copyright © 1992 by Society for Neuroscience
Postsynaptic, but not presynaptic, activity controls the early time course of long-term potentiation in the dentate gyrus
E Hanse and B Gustafsson
Department of Physiology, University of Goteborg, Sweden.
The early time course (less than 1 hr) of long-term potentiation (LTP) in
the dentate gyrus of the guinea pig hippocampal slice was examined using
extracellular recordings from the outer two-thirds of the dendritic layer.
LTP was induced by a single brief (2-40 impulses) high- frequency (20-400
Hz) train, or by pairing a single test stimulus with a brief heterosynaptic
high-frequency train. The induction of LTP was facilitated by blockade of
fast GABAergic postsynaptic inhibition. It was found that, irrespective of
induction conditions and the amount of LTP induced, the onset of LTP was
characterized by a latency of a few seconds following the induction event,
and a rapid 30 sec growth phase. After a 1-2 min period of little or no
further growth, LTP decayed but in a highly variable manner, from cases in
which more than 60% of the peak value remained 1 hr after the induction to
cases in which LTP decayed completely within 10 min. Factors increasing
presynaptic activity (frequency or number of afferent stimulations) during
the induction event did not affect the relative amount of LTP decay.
Repetitive presynaptic activity was found not to be a necessary condition
for eliciting long-lasting LTP (greater than 1 hr), as shown by experiments
in which a single presynaptic impulse was paired with a brief
heterosynaptic train. Factors increasing postsynaptic activity during the
induction event, such as increased stimulus intensity, temporal pairing of
two weak trains, or reduced postsynaptic inhibition, all reduced the
relative amount of LTP decay. Moreover, partial pharmacological blockade of
NMDA receptor channels increased the relative amount of decay. In
conclusion, the amount of postsynaptic activity and associated NMDA
receptor activation during the induction event appeared to be the main
factor governing the early stability of LTP in the dentate gyrus.
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