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Journal of Neuroscience, Vol 12, 3241-3247, Copyright © 1992 by Society for Neuroscience
Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor
ME Gurney, H Yamamoto and Y Kwon
Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611.
Ciliary neurotrophic factor (CNTF) and basic fibroblast growth factor
(bFGF) were tested for effects on sprouting by motor neurons innervating
the adult mouse gluteus muscle. Factors were delivered by subcutaneous
injection directly over the surface of the superior gluteus muscle once
daily for 7 d and then end plates and axons were visualized by combined
silver and cholinesterase staining. CNTF (500 ng daily) induced sprouting
both from end plates and from the subset of nodes of Ranvier that are
closest to the end plate. The effect of CNTF was potentiated twofold by
coadministration of bFGF at doses of 2-20 ng daily, whereas treatment with
bFGF alone failed to induce sprouting from either end plates or nodes of
Ranvier. The sprouting stimulus delivered by the factors showed limited
penetrance into the muscle and restricted lateral spread from the injection
site.
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