 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 12, 3525-3534, Copyright © 1992 by Society for Neuroscience
Restricted expression of N- and R-cadherin on neurites of the developing chicken CNS
C Redies, H Inuzuka and M Takeichi
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
The expression of two cadherins, N- and R-cadherin, was mapped in the CNS
of chicken embryos of 6-11 d incubation, focusing on the sensory and motor
fiber systems. In the spinal cord, the laterally located fibers of the
dorsal funiculus express N-cadherin while the medially located fibers do
not. These two fiber systems have a different course within the CNS but
associate to form the spinal dorsal roots. In the hindbrain, N-cadherin is
expressed by the descending trigeminal (general somatic sensory) tract,
which is contiguous with the N- cadherin-positive zone of the dorsal
funiculus of the spinal cord. R- cadherin is not expressed by sensory
fibers, but is expressed by the visceral motor system of the vagus and
glossopharyngeal nerves, which are N-cadherin negative. The motor neurites
expressing R-cadherin have a different course within the brain than the
sensory neurites expressing N-cadherin, although they form the common
sensory/motor roots of the vagus nerve at the surface of the brain. The
possibility that N-cadherin provides a guidance cue for sensory axon
migration within the CNS by a homophilic adhesion mechanism was
investigated in vitro. Explants from sensory spinal ganglia expressing
N-cadherin were placed on N-cadherin-transfected neuroblastoma cells, and
axon outgrowth was visualized. Results showed that the sensory axons
defasciculate and closely follow the cell-cell boundaries between
transfected cells where high levels of N-cadherin are expressed. These
results show that the two cadherins, like members of the immunoglobulin
superfamily of molecules, are expressed in a topographically restricted
fashion during chick brain development. They furthermore suggest that N-
cadherin expression by neurites may play a role in guiding these neurites
along CNS paths that express the same molecule.
This article has been cited by other articles:
|
|
|
|
 
C. E. Shiau and M. Bronner-Fraser
N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons
Development,
December 15, 2009;
136(24):
4155 - 4164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Halbleib and W. J. Nelson
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
Genes & Dev.,
December 1, 2006;
20(23):
3199 - 3214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Treubert-Zimmermann, D. Heyers, and C. Redies
Targeting Axons to Specific Fiber Tracts In Vivo by Altering Cadherin Expression
J. Neurosci.,
September 1, 2002;
22(17):
7617 - 7626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Benson and H. Tanaka
N-Cadherin Redistribution during Synaptogenesis in Hippocampal Neurons
J. Neurosci.,
September 1, 1998;
18(17):
6892 - 6904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. I. I. Ganzler-Odenthal and C. Redies
Blocking N-Cadherin Function Disrupts the Epithelial Structure of Differentiating Neural Tissue in the Embryonic Chicken Brain
J. Neurosci.,
July 15, 1998;
18(14):
5415 - 5425.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Shibata, Y. Shimoyama, M. Gotoh, and S. Hirohashi
Identification of Human Cadherin-14, a Novel Neurally Specific Type II Cadherin, by Protein Interaction Cloning
J. Biol. Chem.,
February 21, 1997;
272(8):
5236 - 5240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Takeichi, T. Uemura, Y. Iwai, N. Uchida, T. Inoue, T. Tanaka, and S.C. Suzuki
Cadherins in Brain Patterning and Neural Network Formation
Cold Spring Harb Symp Quant Biol,
January 1, 1997;
62(0):
505 - 510.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H Tanihara, M Kido, S Obata, R. Heimark, M Davidson, T St John, and S Suzuki
Characterization of cadherin-4 and cadherin-5 reveals new aspects of cadherins
J. Cell Sci.,
January 6, 1994;
107(6):
1697 - 1704.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H Matsunami, S Miyatani, T Inoue, N. Copeland, D. Gilbert, N. Jenkins, and M Takeichi
Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene
J. Cell Sci.,
January 9, 1993;
106(1):
401 - 409.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L.F. Reichardt, B. Bossy, I. de Curtis, K.M. Neugebauer, K. Venstrom, and D. Sretavan
Adhesive Interactions That Regulate Development of the Retina and Primary Visual Projection
Cold Spring Harb Symp Quant Biol,
January 1, 1992;
57(0):
419 - 429.
[Abstract]
[PDF]
|
|
|
|
|
