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Journal of Neuroscience, Vol 12, 3619-3627, Copyright © 1992 by Society for Neuroscience
Temporal chimeras produced by hypothalamic transplants
MA Vogelbaum and M Menaker
Department of Biology, University of Virginia, Charlottesville 22901.
The expression of locomotor activity by golden hamsters is temporally
controlled by circadian oscillators contained within the suprachiasmatic
nuclei. A genetic mutation has been found that alters the freerunning
period of the locomotor activity rhythm from the wild- type value of
approximately 24 to approximately 20 hr in homozygous mutants. It has been
shown previously that a transplant of fetal hypothalamic tissue containing
the suprachiasmatic nuclei to a host rendered arrhythmic by a complete
lesion of the suprachiasmatic nuclei restores rhythmicity with the
freerunning period that is normally expressed by the donor genotype. We
made partial lesions of the suprachiasmatic nuclei of wild-type hosts,
which did not completely abolish their circadian rhythmicity, and then
placed hypothalamic implants from homozygous mutant fetal donors into the
lesion site. The resulting complex patterns of locomotor activity contain
rhythmic components with periods of both host and donor circadian
oscillators, and suggest the presence of both stimulatory and inhibitory
inputs from the circadian system to the centers controlling locomotor
behavior.
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