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 Previous Article
Journal of Neuroscience, Vol 12, 3700-3715, Copyright © 1992 by Society for Neuroscience
Anatomy and physiology of multipolar cells in the rat inferior collicular cortex using the in vitro brain slice technique
PH Smith
Department of Anatomy, University of Wisconsin, Madison 53706.
Coronal brain slices from 21-50-d-old hooded rats were used to characterize
intracellular responses of cells in both the external and dorsal cortices
of the inferior colliculus (IC). These cells could generate both sodium and
calcium spikes. Depending on current amplitude, depolarizing current pulses
could elicit either phasic or tonic firing patterns, with spike frequency
adaptation. Spiking also occurred at the offset of a hyperpolarizing pulse.
These patterns were due primarily to the activation of calcium
conductances. Stimulation of the commissural pathway connecting the left
and right IC produced a short-latency monosynaptic IPSP followed by an
EPSP(s) and a late polysynaptic IPSP(s). Non-NMDA glutamate antagonists
eliminated or reduced the amplitude of the EPSP and the late portion of the
inhibition, while both IPSPs were blocked by GABAA antagonists. As
described previously in guinea pig (Smith, 1986) and rat (Pierson et al.,
1989), a large NMDA-mediated depolarizing event (paroxysmal depolarizing
shift, or PDS) could be elicited by shocking the commissure of the IC in
the presence of picrotoxin or bicuculline, NMDA, 4-aminopyridine, or in 0
Mg2+ Ringer's. The picrotoxin-induced PDS was significantly reduced or
abolished in Ringer's containing aminophosphonovalerate. Cells displaying
the responses described were labeled with neurobiotin. Those labeled are
medium-sized multipolar cells. Their dendrites are usually spiny and can
extend superficially up to the cortical surface. Their thin axons give rise
to collaterals that branch profusely within the cortex. The main axons
project laterally along the circumference of the IC or medially into the
commissure separating the collicular hemispheres.
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