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Journal of Neuroscience, Vol 13, 1-12, Copyright © 1993 by Society for Neuroscience
Activation of single neurons in the rat nucleus accumbens during self- stimulation of the ventral tegmental area
M Wolske, PP Rompre, RA Wise and MO West
Department of Psychology, Rutgers, State University, New Brunswick, New Jersey 08903.
Single neurons (n = 76) were recorded in the nucleus accumbens septi (NAS)
of rats self-stimulating the ipsilateral medial forebrain bundle (MFB) at
the level of the ventral tegmental area (VTA). Responses evoked by
rewarding trains of stimulus pulses fell into five categories. The first
category (40% of the sample) was characterized by a single discharge at
invariant latency in response to individual pulses of the train, and hence
was termed "tightly time locked" (TTL). Two TTL neurons were collision
tested, and both showed collision, suggesting that self-stimulation of the
VTA may involve antidromic, and thus direct, activation of a substantial
number of NAS axons. The second category (26%) was characterized by
discharges that varied in latency from pulse to pulse and hence was termed
"loosely time locked" (LTL). Responses of the remainder of the sample
showed no coupling to individual pulses but were categorized based on
general firing patterns during the train: excited (7%), inhibited (4%), and
no change (23%). Irrespective of category, immediately after the
self-stimulation session, the likelihood of evoked discharge at
monosynaptic latency by single pulse stimulation of the ipsilateral fimbria
was reduced (relative to pre-session level), concurrent with elevations in
mean firing rate and motor activity. NAS neurons thus exhibit vigorous
activation, apparently both antidromically and orthodromically, in response
to VTA self-stimulation. The responses of certain LTL and TTL neurons
increased as a function of pulse number in the train, suggestive of
integrative mechanisms important for brain stimulation reward. Conduction
velocities of directly activated (TTL) axons (0.41- 0.65 m/sec) were slower
than those previously reported for first-stage, reward-relevant axons.
Nonetheless, an implication of direct activation of NAS (and other MFB)
axons is that rewarding stimulation triggers action potentials that could
invade all axonal branches, including those between the stimulation site
and the soma, and send synaptic signals to target neurons. Such signals
from NAS neurons could contribute to the increased motor behavior
accompanying MFB self- stimulation, and/or could interact with
dopamine-mediated signals projected to the NAS from reward circuitry.
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