 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 13, 285-299, Copyright © 1993 by Society for Neuroscience
Initial tract formation in the mouse brain
SS Easter Jr, LS Ross and A Frankfurter
Department of Biology, University of Michigan, Ann Arbor 48109-1048.
Mouse embryos from embryonic days 8.5-10.5 (E8.5-E10.5) were fixed and
labeled with an antibody to neuron-specific class III beta-tubulin (Moody
et al., 1987; Lee et al., 1990a,b) to reveal the first neurons, axons, and
tracts in the brain. They were studied in whole-mounts and in light
microscopic sections. Some conclusions were checked by labeling tracts in
older embryos (E11.5 and E12.5) with the lipophilic dye
1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine. The first
immunoreactive cells appeared at E8.5, prior to neural tube closure, in the
neural plate immediately caudal to the optic vesicle. Cells along the
dorsal midline of the mesencephalon issued the first axons, on E9.0; the
cells were the mesencephalic nucleus of the trigeminal nerve, and the axons
formed its descending tract. The tract reached the level of the trigeminal
ganglion by E10.0 but did not enter the ganglion until after E12.5. On
E9.5, the number of labeled cells and axons in the alar plate of the
presumptive diencephalon and mesencephalon had increased substantially, and
many of the rostral ones coursed into the basal plate to enter longitudinal
tracts there. Two tracts originated from cells in the basal plate: the
tract of the postoptic commissure (from the base of the optic stalk to the
level of the cephalic flexure) and the medial longitudinal fasciculus (from
the level of the cephalic flexure caudally through the mid and
hind-brains). By E10.0, a small mammillotegmental tract paralleled the
tract of the postoptic commissure, but immunolabeling was so widespread
that discrete tracts were impossible to discern in the presumptive
diencephalon and mesencephalon. The more rostral regions remained lightly
labeled. In the cerebral vesicle, the presumptive cerebral cortex, the
first immunoreactive cells appeared at E10.0; they had multiple processes
oriented parallel to the pia, and were identified as the Cajal-Retzius
cells. By E10.5, no tracts had formed in the cerebral vesicle. All the
tracts formed by E10.0 were superficial, in the subpial lamina. Those that
can be identified in the adult brain are very deep structures. These
results are compared with previous descriptions of the embryonic brains of
amphibians, fish, birds, and other mammals, including humans.
This article has been cited by other articles:
|
|
|
|
 
E. Kastenhuber, U. Kern, J. L. Bonkowsky, C.-B. Chien, W. Driever, and J. Schweitzer
Netrin-DCC, Robo-Slit, and Heparan Sulfate Proteoglycans Coordinate Lateral Positioning of Longitudinal Dopaminergic Diencephalospinal Axons
J. Neurosci.,
July 15, 2009;
29(28):
8914 - 8926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.-M. Jouhilahti, S. Peltonen, and J. Peltonen
Class III {beta}-Tubulin Is a Component of the Mitotic Spindle in Multiple Cell Types
J. Histochem. Cytochem.,
December 1, 2008;
56(12):
1113 - 1119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. T. Farmer, A. L. Altick, H. F. Nural, J. P. Dugan, T. Kidd, F. Charron, and G. S. Mastick
Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals
Development,
November 15, 2008;
135(22):
3643 - 3653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Szokol, J. C. Glover, and M.-C. Perreault
Differential origin of reticulospinal drive to motoneurons innervating trunk and hindlimb muscles in the mouse revealed by optical recording
J. Physiol.,
November 1, 2008;
586(21):
5259 - 5276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. E. Frigo and D. P. McDonnell
Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation
Mol. Cancer Ther.,
March 1, 2008;
7(3):
659 - 669.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hiratochi, H. Nagase, Y. Kuramochi, C.-S. Koh, T. Ohkawara, and K. Nakayama
The Delta intracellular domain mediates TGF-{beta}/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway
Nucleic Acids Res.,
February 16, 2007;
35(3):
912 - 922.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Browd, A. M. Kenney, O. N. Gottfried, J. W. Yoon, D. Walterhouse, C. A. Pedone, and D. W. Fults
N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog-Induced Medulloblastoma.
Cancer Res.,
March 1, 2006;
66(5):
2666 - 2672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Qin, L. Wine-Lee, K. J. Ahn, and E. B. Crenshaw III
Genetic Analyses Demonstrate That Bone Morphogenetic Protein Signaling Is Required for Embryonic Cerebellar Development
J. Neurosci.,
February 15, 2006;
26(7):
1896 - 1905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Cowan, J. Atienza, D. A. Melton, and K. Eggan
Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells
Science,
August 26, 2005;
309(5739):
1369 - 1373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. R. Schubert and A. Lumsden
Transcriptional control of early tract formation in the embryonic chick midbrain
Development,
April 15, 2005;
132(8):
1785 - 1793.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Song, Y.-C. Lu, K. Yokoyama, J. Rossi, and R. Chiu
Cyclophilin A Is Required for Retinoic Acid-induced Neuronal Differentiation in p19 Cells
J. Biol. Chem.,
June 4, 2004;
279(23):
24414 - 24419.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Cowan, I. Klimanskaya, J. McMahon, J. Atienza, J. Witmyer, J. P. Zucker, S. Wang, C. C. Morton, A. P. McMahon, D. Powers, et al.
Derivation of Embryonic Stem-Cell Lines from Human Blastocysts
N. Engl. J. Med.,
March 25, 2004;
350(13):
1353 - 1356.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Katsetos, A. Legido, E. Perentes, and S. J. Mork
Class III {beta}-Tubulin Isotype: A Key Cytoskeletal Protein at the Crossroads of Developmental Neurobiology and Tumor Neuropathology
J Child Neurol,
December 1, 2003;
18(12):
851 - 866.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. L. Andrews and G. S. Mastick
R-Cadherin Is a Pax6-Regulated, Growth-Promoting Cue for Pioneer Axons
J. Neurosci.,
October 29, 2003;
23(30):
9873 - 9880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Gust, J J Wright, E B Pratt, and M M Bosma
Development of synchronized activity of cranial motor neurons in the segmented embryonic mouse hindbrain
J. Physiol.,
July 1, 2003;
550(1):
123 - 133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. C. Luk, T. E. Kennedy, and A. F. Sadikot
Glutamate Promotes Proliferation of Striatal Neuronal Progenitors by an NMDA Receptor-Mediated Mechanism
J. Neurosci.,
March 15, 2003;
23(6):
2239 - 2250.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Agarwala and C. W. Ragsdale
A role for midbrain arcs in nucleogenesis
Development,
March 14, 2003;
129(24):
5779 - 5788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Estivill-Torrus, H. Pearson, V. van Heyningen, D. J. Price, and P. Rashbass
Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors
Development,
March 3, 2003;
129(2):
455 - 466.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Sanders, A. Lumsden, and C. W. Ragsdale
Arcuate Plan of Chick Midbrain Development
J. Neurosci.,
December 15, 2002;
22(24):
10742 - 10750.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Spassky, F. de Castro, B. Le Bras, K. Heydon, F. Queraud-LeSaux, E. Bloch-Gallego, A. Chedotal, B. Zalc, and J.-L. Thomas
Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1
J. Neurosci.,
July 15, 2002;
22(14):
5992 - 6004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Rachel, G. Dolen, N. L. Hayes, A. Lu, L. Erskine, R. S. Nowakowski, and C. A. Mason
Spatiotemporal Features of Early Neuronogenesis Differ in Wild-Type and Albino Mouse Retina
J. Neurosci.,
June 1, 2002;
22(11):
4249 - 4263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Buzanska, E. K. Machaj, B. Zablocka, Z. Pojda, and K. Domanska-Janik
Human cord blood-derived cells attain neuronal and glial features in vitro
J. Cell Sci.,
May 15, 2002;
115(10):
2131 - 2138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Spassky, K. Heydon, A. Mangatal, A. Jankovski, C. Olivier, F. Queraud-Lesaux, C. Goujet-Zalc, J. L. Thomas, and B. Zalc
Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFR{alpha} signaling
Development,
December 15, 2001;
128(24):
4993 - 5004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ichijo and I. Kawabata
Roles of the Telencephalic Cells and their Chondroitin Sulfate Proteoglycans in Delimiting an Anterior Border of the Retinal Pathway
J. Neurosci.,
December 1, 2001;
21(23):
9304 - 9314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Middleton and A. M. Davies
Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo
Development,
December 1, 2001;
128(23):
4715 - 4728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Pencea, K. D. Bingaman, S. J. Wiegand, and M. B. Luskin
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus
J. Neurosci.,
September 1, 2001;
21(17):
6706 - 6717.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Coskun and M. B. Luskin
The Expression Pattern of the Cell Cycle Inhibitor p19INK4d by Progenitor Cells of the Rat Embryonic Telencephalon and Neonatal Anterior Subventricular Zone
J. Neurosci.,
May 1, 2001;
21(9):
3092 - 3103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Stuckmann, A. Weigmann, A. Shevchenko, M. Mann, and W. B. Huttner
Ephrin B1 Is Expressed on Neuroepithelial Cells in Correlation with Neocortical Neurogenesis
J. Neurosci.,
April 15, 2001;
21(8):
2726 - 2737.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Trejo, E. Carro, and I. Torres-Aleman
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus
J. Neurosci.,
March 1, 2001;
21(5):
1628 - 1634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Easter Jr. and P. F. Hitchcock
Stem Cells and Regeneration in the Retina: What Fish Have Taught Us about Neurogenesis
Neuroscientist,
December 1, 2000;
6(6):
454 - 464.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. M. Soria and A. Fairen
Cellular Mosaics in the Rat Marginal Zone Define an Early Neocortical Territorialization
Cereb Cortex,
April 1, 2000;
10(4):
400 - 412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Glover
Development of Specific Connectivity Between Premotor Neurons and Motoneurons in the Brain Stem and Spinal Cord
Physiol Rev,
April 1, 2000;
80(2):
615 - 647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mallamaci, S. Mercurio, L. Muzio, C. Cecchi, C. L. Pardini, P. Gruss, and E. Boncinelli
The Lack of Emx2 Causes Impairment of Reelin Signaling and Defects of Neuronal Migration in the Developing Cerebral Cortex
J. Neurosci.,
February 1, 2000;
20(3):
1109 - 1118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G Alvarez-Bolado, X Zhou, A. Voss, T Thomas, and P Gruss
Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus
Development,
January 3, 2000;
127(5):
1029 - 1038.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Farah, J. Olson, H. Sucic, R. Hume, S. Tapscott, and D. Turner
Generation of neurons by transient expression of neural bHLH proteins in mammalian cells
Development,
January 2, 2000;
127(4):
693 - 702.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P Daubas, S Tajbakhsh, J Hadchouel, M Primig, and M Buckingham
Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons
Development,
January 1, 2000;
127(2):
319 - 331.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. S. Deiner and D. W. Sretavan
Altered Midline Axon Pathways and Ectopic Neurons in the Developing Hypothalamus of Netrin-1- and DCC-Deficient Mice
J. Neurosci.,
November 15, 1999;
19(22):
9900 - 9912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Saueressig, J Burrill, and M Goulding
Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons
Development,
January 10, 1999;
126(19):
4201 - 4212.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Orentas, J. Hayes, K. Dyer, and R. Miller
Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors
Development,
January 6, 1999;
126(11):
2419 - 2429.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K Hentges, K Thompson, and A Peterson
The flat-top gene is required for the expansion and regionalization of the telencephalic primordium
Development,
January 4, 1999;
126(8):
1601 - 1609.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. Spassky, C. Goujet-Zalc, E. Parmantier, C. Olivier, S. Martinez, A. Ivanova, K. Ikenaka, W. Macklin, I. Cerruti, B. Zalc, et al.
Multiple Restricted Origin of Oligodendrocytes
J. Neurosci.,
October 15, 1998;
18(20):
8331 - 8343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sato, T. Hirata, M. Ogawa, and H. Fujisawa
Requirement for Early-Generated Neurons Recognized by Monoclonal Antibody Lot1 in the Formation of Lateral Olfactory Tract
J. Neurosci.,
October 1, 1998;
18(19):
7800 - 7810.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Hallows and B. L. Tempel
Expression of Kv1.1, a Shaker-Like Potassium Channel, Is Temporally Regulated in Embryonic Neurons and Glia
J. Neurosci.,
August 1, 1998;
18(15):
5682 - 5691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kruger, A. S. Tam, C. Lu, and D. W. Sretavan
Retinal Ganglion Cell Axon Progression from the Optic Chiasm to Initiate Optic Tract Development Requires Cell Autonomous Function of GAP-43
J. Neurosci.,
August 1, 1998;
18(15):
5692 - 5705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gondre, P. Burrola, and D. E. Weinstein
Accelerated Nerve Regeneration Mediated by Schwann Cells Expressing a Mutant Form of the POU Protein SCIP
J. Cell Biol.,
April 20, 1998;
141(2):
493 - 501.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ba-Charvet, Y von Boxberg, S Guazzi, E Boncinelli, and P Godement
A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
Development,
January 11, 1998;
125(21):
4273 - 4282.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R Tuttle, J. Braisted, L. Richards, and D. O'Leary
Retinal axon guidance by region-specific cues in diencephalon
Development,
January 3, 1998;
125(5):
791 - 801.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Caldero, D. Prevette, X. Mei, R. A. Oakley, L. Li, C. Milligan, L. Houenou, M. Burek, and R. W. Oppenheim
Peripheral Target Regulation of the Development and Survival of Spinal Sensory and Motor Neurons in the Chick Embryo
J. Neurosci.,
January 1, 1998;
18(1):
356 - 370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Lim, G. J. Fishell, and A. Alvarez-Buylla
Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis
PNAS,
December 23, 1997;
94(26):
14832 - 14836.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Fritzsch, I. Farinas, and L. F. Reichardt
Lack of Neurotrophin 3 Causes Losses of Both Classes of Spiral Ganglion Neurons in the Cochlea in a Region-Specific Fashion
J. Neurosci.,
August 15, 1997;
17(16):
6213 - 6225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Doetsch, J. M. Garcia-Verdugo, and A. Alvarez-Buylla
Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
J. Neurosci.,
July 1, 1997;
17(13):
5046 - 5061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Parent, T. W. Yu, R. T. Leibowitz, D. H. Geschwind, R. S. Sloviter, and D. H. Lowenstein
Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus
J. Neurosci.,
May 15, 1997;
17(10):
3727 - 3738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Richards, S. E. Koester, R. Tuttle, and D. D. M. O'Leary
Directed Growth of Early Cortical Axons Is Influenced by a Chemoattractant Released from an Intermediate Target
J. Neurosci.,
April 1, 1997;
17(7):
2445 - 2458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Mastick, N. Davis, G. Andrew, and S. Easter
Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain
Development,
January 5, 1997;
124(10):
1985 - 1997.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E Cau, G Gradwohl, C Fode, and F Guillemot
Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors
Development,
January 4, 1997;
124(8):
1611 - 1621.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. Doetsch and A. Alvarez-Buylla
Network of tangential pathways for neuronal migration in adult mammalian brain
PNAS,
December 10, 1996;
93(25):
14895 - 14900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Wilkinson, I. Farinas, C. Backus, C. K. Yoshida, and L. F. Reichardt
Neurotrophin-3 Is a Survival Factor In Vivo for Early Mouse Trigeminal Neurons
J. Neurosci.,
December 1, 1996;
16(23):
7661 - 7669.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Redmond, S. Hockfield, and M. A. Morabito
The Divergent Homeobox Gene PBX1 Is Expressed in the Postnatal Subventricular Zone and Interneurons of the Olfactory Bulb
J. Neurosci.,
May 1, 1996;
16(9):
2972 - 2982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Millet, E Bloch-Gallego, A Simeone, and R. Alvarado-Mallart
The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts
Development,
January 12, 1996;
122(12):
3785 - 3797.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Sretavan, E Pure, M. Siegel, and L. Reichardt
Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons
Science,
July 7, 1995;
269(5220):
98 - 101.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. M. Sheppard, J. J. McQuillan, M. F. Iademarco, and D. C. Dean
Control of Vascular Cell Adhesion Molecule-1 Gene Promoter Activity during Neural Differentiation
J. Biol. Chem.,
February 24, 1995;
270(8):
3710 - 3719.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Shimamura, D. Hartigan, S Martinez, L Puelles, and J. Rubenstein
Longitudinal organization of the anterior neural plate and neural tube
Development,
January 12, 1995;
121(12):
3923 - 3933.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S Tajbakhsh and M. Buckingham
Lineage restriction of the myogenic conversion factor myf-5 in the brain
Development,
January 12, 1995;
121(12):
4077 - 4083.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S Therianos, S Leuzinger, F Hirth, C. Goodman, and H Reichert
Embryonic development of the Drosophila brain: formation of commissural and descending pathways
Development,
January 11, 1995;
121(11):
3849 - 3860.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Hall and S. MacPhedran
Multiple mechanisms regulate sympathetic neuronal phenotype
Development,
January 8, 1995;
121(8):
2361 - 2371.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C van Genderen, R M Okamura, I Farinas, R G Quo, T G Parslow, L Bruhn, and R Grosschedl
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.
Genes & Dev.,
November 15, 1994;
8(22):
2691 - 2703.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Emerling and A. Lander
Laminar specific attachment and neurite outgrowth of thalamic neurons on cultured slices of developing cerebral neocortex
Development,
January 10, 1994;
120(10):
2811 - 2822.
[Abstract]
[PDF]
|
|
|
|
|
