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Journal of Neuroscience, Vol 13, 4214-4219, Copyright © 1993 by Society for Neuroscience
Transport of BC1 RNA in hypothalamo-neurohypophyseal axons
H Tiedge, A Zhou, NA Thorn and J Brosius
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029.
Ample evidence indicates that in nerve cells, several individual proteins
are locally synthesized in postsynaptic domains in dendrites. By contrast,
axonal terminals, at least in mammals, are generally thought to lack
protein synthetic capacity. However, axonal nerve endings of the
hypothalamo-neurohypophyseal tract have recently been shown to contain
mRNAs encoding vasopressin, oxytocin, dynorphin, and neurofilament. In this
report, we identify BC1 RNA, a small RNA polymerase III transcript that is
specifically expressed in neurons, in hypothalamo-neurohypophyseal axons.
BC1 RNA has previously been shown to be located in somatic and dendritic
domains of various types of neurons in the rat nervous system. Here we
present evidence to show that BC 1 RNA, like several neuropeptide mRNAs, is
axonally transported from magnocellular hypothalamic neurons to
neurosecretory nerve endings in the posterior pituitary. BC1 RNA, which has
been reported to be a component of a ribonucleoprotein particle, is thus
colocalized with dendritic mRNAs in dendritic domains and with axonal mRNAs
in axonal domains, respectively. Such colocalization is indicative of
functional interactions of BC1 RNA with those mRNAs that are targeted to
extrasomatic domains of nerve cells.
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