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Journal of Neuroscience, Vol 13, 4961-4967, Copyright © 1993 by Society for Neuroscience
Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons
AM Davies, A Horton, LE Burton, C Schmelzer, R Vandlen and A Rosenthal
School of Biological and Medical Sciences, St. Andrews University, Fife, Scotland.
We have studied the effect of human recombinant neurotrophin-4/5 (NT- 4/5)
on the survival of developing PNS neurons from embryonic mice and chickens.
NT-4/5 transiently supported mouse NGF-dependent trigeminal and jugular
neurons at early stages of target field innervation and mouse brain-derived
neurotrophic factor (BDNF)-dependent no-dose neurons during the phase of
naturally occurring cell death. NT-4/5 was as potent as BDNF in supporting
the survival of these neuronal populations. Surprisingly, NT-4/5 was 3
orders of magnitude less potent than BDNF as a survival factor for early
chick dorsomedial trigeminal sensory neurons and did not support the
survival of chick BDNF- dependent trigeminal mesencephalic or ventrolateral
trigeminal sensory neurons at any of the developmental stages tested. Thus,
NT-4/5 is a survival factor for certain embryonic mouse cranial sensory
neurons. It is the first species-specific neurotrophin to be identified and
it can discriminate at high concentrations between different
BDNF-responsive chick neurons.
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