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Journal of Neuroscience, Vol 13, 5056-5065, Copyright © 1993 by Society for Neuroscience
Intragenic sequences are required for cell type-specific and injury- induced expression of the rat peripherin gene
T Belecky-Adams, DC Wight, JJ Kopchick and LM Parysek
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Ohio 45267-0521.
Peripherin is a 57 kDa type III intermediate-filament protein that is
thought to play a role in axonogenesis both during development and
following nerve injury (Oblinger et al., 1989; Escurat et al., 1990; Gorham
et al., 1990; Troy et al., 1990b). We have used transgenic mouse technology
to define peripherin gene sequences that are necessary for cell
type-specific expression and for the increase in peripherin that occurs in
response to axonal injury. Correct temporal and nervous system-specific
expression resulted when 5.8 kilobases of peripherin 5' flanking sequence
were linked to a reporter gene, but precise cell type- specific expression
was achieved only when intragenic sequences were included. When intragenic
sequences were present, peripherin transgenes were expressed in dorsal root
ganglion neurons and spinal cord motor neurons and were upregulated in
these cells following nerve injury.
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