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Journal of Neuroscience, Vol 13, 5082-5091, Copyright © 1993 by Society for Neuroscience
Differential expression of hyperpolarization-activated currents reveals distinct classes of visual cortical projection neurons
JS Solomon, JF Doyle, A Burkhalter and JM Nerbonne
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110.
Combining in vivo retrograde labeling and in vitro electrophysiological
recording techniques, we examined the distributions, densities, and
biophysical properties of hyperpolarization-activated inward currents in
two types of isolated, identified visual cortical projection neurons,
superior colliculus-projecting (SCP) and callosal-projecting (CP) cells. In
SCP cells, two kinetically distinct time-dependent
hyperpolarization-activated inward current components are present. We have
termed these Ih,f and Ih,s to denote the fast and slow components,
respectively, of Ih activation. In CP cells, in contrast, Ih,f and Ih,s are
differentially expressed. In 59% of the CP cells examined, for example,
both Ih,f and Ih,s were present. The properties of the currents are
indistinguishable from those recorded from SCP cells, although both Ih,f
and Ih,s are expressed at significantly lower densities in this subset of
CP cells (as compared to the current densities in SCP cells). Of the
remaining 41% of the CP cells studied, 26% were found to express only Ih,s,
and 12% of the cells expressed neither Ih,f nor Ih,s. Taken together, these
results reveal that the electrical properties of CP visual cortical neurons
are considerably more heterogeneous than those of SCP cells. The
differential expression of Ih,f and Ih,s is expected to influence the
integrated responses of different types of cortical projection neurons to
excitatory and inhibitory synaptic inputs.
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