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Journal of Neuroscience, Vol 13, 5402-5406, Copyright © 1993 by Society for Neuroscience
The striopallidal neuron: a main locus for adenosine-dopamine interactions in the brain
S Ferre, WT O'Connor, K Fuxe and U Ungerstedt
Department of Neurochemistry, C.S.I.C., Barcelona, Spain.
Recent pharmacological data suggest that a receptor-receptor interaction
between adenosine A2 and dopamine D2 receptors in the brain underlies the
behavioral effects of adenosine agonists and adenosine antagonists, such as
caffeine and theophylline. According to this interaction, stimulation of A2
receptors inhibits and their blockade potentiates the effects of D2
receptor stimulation. Furthermore, both A2 and D2 receptors are selectively
colocalized on GABAergic striopallidal neurons. In this microdialysis
investigation the effect of intrastriatal infusion of adenosine and
dopamine agonists and antagonists alone or in combination was studied on
the release of GABA from the terminals of the striopallidal neuron in
awake, freely moving rats. We report that the GABAergic striopallidal
neuron, which is a key component of the indirect striatal efferent pathway,
is a main locus for A2-D2 interactions in the brain and possibly a main
target for the central actions of adenosine agonists and antagonists.
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