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Journal of Neuroscience, Vol 13, 5407-5417, Copyright © 1993 by Society for Neuroscience
Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
CM Loer and CJ Kenyon
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
Defining a behavior that requires the function of specific neurons in the
free-living nematode Caenorhabditis elegans can allow one to screen for
mutations that disrupt the specification or function of those neurons. We
identified serotonin-immunoreactive neurons required for tail curling or
"turning" behavior exhibited by C. elegans males during mating. Males
mutant in three different genes that reduce serotonin expression, cat-1,
cat-4, and bas-1, exhibited defects in turning behavior similar to those of
wild-type males in which these neurons were ablated. The turning defect of
cat-4 males was rescued by exogenous serotonin, consistent with the idea
that their behavioral defect is caused by a lack of serotonin. While the
serotonin-deficient mutants we analyzed shared certain behavioral traits,
they were blocked for serotonin synthesis at different steps. Analysis of
these and additional serotonin-deficient mutants may help us understand how
a neuron controls the expression of a serotonergic phenotype.
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