Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

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Journal of Neuroscience, Vol 13, 596-604, Copyright © 1993 by Society for Neuroscience

ARTICLE

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

P Seguela, J Wadiche, K Dineley-Miller, JA Dani and JW Patrick
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
A full-length clone coding for the rat alpha 7 nicotinic receptor subunit was isolated from an adult brain cDNA library and expressed in Xenopus oocytes. A significant proportion of the current through alpha 7-channels is carried by Ca2+. This Ca2+ influx then activates a Ca(2+)- dependent Cl- conductance, which is blocked by the chloride channel blockers niflumic and fluflenamic acid. Increasing the external NaCl concentration caused the reversal potentials for the alpha 7-channels and the Ca(2+)-dependent Cl- channels to be shifted in opposite directions. Under these conditions, agonist application activates a biphasic current with an initial inward current through alpha 7- channels followed by a niflumic acid- and fluflenamic acid-blockable outward current through Ca(2+)-dependent Cl- channels. A relative measure of the Ca2+ permeability was made by measuring the shift in the reversal potential caused by adding 10 mM Ca2+ to the external solution. Measurements made in the absence of Cl-, to avoid artifactual current through Ca(2+)-activated Cl- channels, indicate that alpha 7- homooligomeric channels have a greater relative Ca2+ permeability than the other nicotinic ACh receptors. Furthermore, alpha 7-channels have an even greater relative Ca2+ permeability than the NMDA subtype of glutamate receptors. High levels of alpha 7-transcripts were localized by in situ hybridization in the olfactory areas, the hippocampus, the hypothalamus, the amygdala, and the cerebral cortex. These results imply that alpha 7-containing receptors may play a role in activating calcium-dependent mechanisms in specific neuronal populations of the adult rat limbic system.

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Am J Physiol Cell Physiol, November 1, 2002; 283(5): C1454 - C1460.
[Abstract] [Full Text] [PDF]

J. Arredondo, V. T. Nguyen, A. I. Chernyavsky, D. Bercovich, A. Orr-Urtreger, W. Kummer, K. Lips, D. E. Vetter, and S. A. Grando
Central role of {alpha}7 nicotinic receptor in differentiation of the stratified squamous epithelium
J. Cell Biol., October 28, 2002; 159(2): 325 - 336.
[Abstract] [Full Text] [PDF]

H. Kawai, W. Zago, and D. K. Berg
Nicotinic alpha 7 Receptor Clusters on Hippocampal GABAergic Neurons: Regulation by Synaptic Activity and Neurotrophins
J. Neurosci., September 15, 2002; 22(18): 7903 - 7912.
[Abstract] [Full Text] [PDF]

X. Zhou, J. Ren, E. Brown, D. Schneider, Y. Caraballo-Lopez, and J. J. Galligan
Pharmacological Properties of Nicotinic Acetylcholine Receptors Expressed by Guinea Pig Small Intestinal Myenteric Neurons
J. Pharmacol. Exp. Ther., September 1, 2002; 302(3): 889 - 897.
[Abstract] [Full Text] [PDF]

K. T. Dineley, K. A. Bell, D. Bui, and J. D. Sweatt
beta -Amyloid Peptide Activates alpha 7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
J. Biol. Chem., July 5, 2002; 277(28): 25056 - 25061.
[Abstract] [Full Text] [PDF]

S. Nirthanan, E. Charpantier, P. Gopalakrishnakone, M. C. E. Gwee, H.-E. Khoo, L.-S. Cheah, D. Bertrand, and R. M. Kini
Candoxin, a Novel Toxin from Bungarus candidus, Is a Reversible Antagonist of Muscle (alpha beta gamma delta ) but a Poorly Reversible Antagonist of Neuronal alpha 7 Nicotinic Acetylcholine Receptors
J. Biol. Chem., May 10, 2002; 277(20): 17811 - 17820.
[Abstract] [Full Text] [PDF]

E. Palma, A. M. Mileo, A. Martinez-Torres, F. Eusebi, and R. Miledi
Some properties of human neuronal alpha 7 nicotinic acetylcholine receptors fused to the green fluorescent protein
PNAS, March 19, 2002; 99(6): 3950 - 3955.
[Abstract] [Full Text] [PDF]

S. Fucile, E. Palma, A. Martinez-Torres, R. Miledi, and F. Eusebi
The single-channel properties of human acetylcholine alpha 7 receptors are altered by fusing alpha 7 to the green fluorescent protein
PNAS, March 19, 2002; 99(6): 3956 - 3961.
[Abstract] [Full Text] [PDF]

Y. Wang, E. F. R. Pereira, A. D. J. Maus, N. S. Ostlie, D. Navaneetham, S. Lei, E. X. Albuquerque, and B. M. Conti-Fine
Human Bronchial Epithelial and Endothelial Cells Express alpha 7 Nicotinic Acetylcholine Receptors
Mol. Pharmacol., December 1, 2001; 60(6): 1201 - 1209.
[Abstract] [Full Text] [PDF]

R. Fabian-Fine, P. Skehel, M. L. Errington, H. A. Davies, E. Sher, M. G. Stewart, and A. Fine
Ultrastructural Distribution of the {alpha}7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus
J. Neurosci., October 15, 2001; 21(20): 7993 - 8003.
[Abstract] [Full Text] [PDF]

J. R. Genzen, W. Van Cleve, and D. S. McGehee
Dorsal Root Ganglion Neurons Express Multiple Nicotinic Acetylcholine Receptor Subtypes
J Neurophysiol, October 1, 2001; 86(4): 1773 - 1782.
[Abstract] [Full Text] [PDF]

L. Maggi, E. Sher, and E. Cherubini
Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus
J. Physiol., October 1, 2001; 536(1): 89 - 100.
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A. Kiyosawa, S. Katsurabayashi, N. Akaike, Z. P. Pang, and N. Akaike
Nicotine facilitates glycine release in the rat spinal dorsal horn
J. Physiol., October 1, 2001; 536(1): 101 - 110.
[Abstract] [Full Text] [PDF]

K. Fujino and D. Oertel
Cholinergic Modulation of Stellate Cells in the Mammalian Ventral Cochlear Nucleus
J. Neurosci., September 15, 2001; 21(18): 7372 - 7383.
[Abstract] [Full Text] [PDF]

Y. Liu, B. Ford, M. A. Mann, and G. D. Fischbach
Neuregulins Increase {alpha}7 Nicotinic Acetylcholine Receptors and Enhance Excitatory Synaptic Transmission in GABAergic Interneurons of the Hippocampus
J. Neurosci., August 1, 2001; 21(15): 5660 - 5669.
[Abstract] [Full Text] [PDF]

Z. J. Zhou
A Critical Role of the Strychnine-Sensitive Glycinergic System in Spontaneous Retinal Waves of the Developing Rabbit
J. Neurosci., July 15, 2001; 21(14): 5158 - 5168.
[Abstract] [Full Text] [PDF]

N. Barazangi and L. W. Role
Nicotine-Induced Enhancement of Glutamatergic and GABAergic Synaptic Transmission in the Mouse Amygdala
J Neurophysiol, July 1, 2001; 86(1): 463 - 474.
[Abstract] [Full Text] [PDF]

K. T. Dineley, M. Westerman, D. Bui, K. Bell, K. H. Ashe, and J. D. Sweatt
{beta}-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal {alpha}7 Nicotinic Acetylcholine Receptors: In Vitro and In Vivo Mechanisms Related to Alzheimer's Disease
J. Neurosci., June 15, 2001; 21(12): 4125 - 4133.
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M. Ferreira, S. N. Ebert, D. C. Perry, R. P. Yasuda, C. M. Baker, M. I. Dávila-García, K. J. Kellar, and R. A. Gillis
Evidence of a Functional alpha 7-Neuronal Nicotinic Receptor Subtype Located on Motoneurons of the Dorsal Motor Nucleus of the Vagus
J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 260 - 269.
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J. P. Hodgkiss and J. S. Kelly
Effect of FK960, a Putative Cognitive Enhancer, on Synaptic Transmission in CA1 Neurons of Rat Hippocampus
J. Pharmacol. Exp. Ther., April 12, 2001; 297(2): 620 - 628.
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X. Zhao, A. Kuryatov, J. M. Lindstrom, J. Z. Yeh, and T. Narahashi
Nootropic Drug Modulation of Neuronal Nicotinic Acetylcholine Receptors in Rat Cortical Neurons
Mol. Pharmacol., April 1, 2001; 59(4): 674 - 683.
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Q.-s. Liu, H. Kawai, and D. K. Berg
beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons
PNAS, March 22, 2001; (2001) 81553598.
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A. B. Belousov, B. F. O'Hara, and J. V. Denisova
Acetylcholine Becomes the Major Excitatory Neurotransmitter in the Hypothalamus In Vitro in the Absence of Glutamate Excitation
J. Neurosci., March 15, 2001; 21(6): 2015 - 2027.
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B. S. Khakh, G. Burnstock, C. Kennedy, B. F. King, R. A. North, P. Seguela, M. Voigt, and P. P. A. Humphrey
International Union of Pharmacology. XXIV. Current Status of the Nomenclature and Properties of P2X Receptors and Their Subunits
Pharmacol. Rev., March 1, 2001; 53(1): 107 - 118.
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E. Lopez, C. Arce, S. Vicente, M.J. Oset-Gasque, and M.P. Gonzalez
Nicotinic Receptors Mediate the Release of Amino Acid Neurotransmitters in Cultured Cortical Neurons
Cereb Cortex, February 1, 2001; 11(2): 158 - 163.
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R. D. Shoop, K. T. Chang, M. H. Ellisman, and D. K. Berg
Synaptically Driven Calcium Transients via Nicotinic Receptors on Somatic Spines
J. Neurosci., February 1, 2001; 21(3): 771 - 781.
[Abstract] [Full Text] [PDF]