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Journal of Neuroscience, Vol 13, 623-631, Copyright © 1993 by Society for Neuroscience
Intracellular calcium levels during the period of delayed excitotoxicity
JM Dubinsky
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
Intracellular calcium concentrations ([Ca2+]i) among cultured hippocampal
neurons were monitored during and in the hours following an excitotoxic
glutamate application to determine the time course of changes involved in
delayed excitotoxicity. After a 5 min toxic insult, [Ca2+]i increased
immediately and remained elevated for an hour. Subsequently, [Ca2+]i
declined to normal resting levels and remained so up to 13 hr following
insult. Only a few neurons displayed greatly elevated [Ca2+]i at these
extended times. Survival experiments in sister cultures indicated that 85%
of the neurons died after 24 hr. Therefore, intracellular calcium returned
to baseline levels prior to neuronal death. Additionally, during this
period when basal calcium levels had recovered, the majority of neurons
responded to a second excitatory amino acid application with a second
increase in [Ca2+]i.
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