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Journal of Neuroscience, Vol 13, 1280-1291, Copyright © 1993 by Society for Neuroscience
Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice
C Suri, BP Fung, AS Tischler and DM Chikaraishi
Neuroscience Program, Tufts University School of Medicine, Boston, Massachusetts 02111.
Brain (CATH.a) and adrenal (PATH.1 and PATH.2) cell lines have been
established that synthesize abundant dopamine and norepinephrine and
express the appropriate catecholaminergic biosynthetic enzymes, tyrosine
hydroxylase (TH) and dopamine beta-hydroxylase. The lines were derived from
TH-positive tumors in transgenic mice carrying the SV40 T antigen oncogene
under the transcriptional control of 773 base pairs of 5' flanking
sequences from the rat TH gene. Although the lines continue to express T
antigen, they exhibit neuronal properties such as neurofilaments and
synaptophysin and lack glial intermediate filaments. Although in vivo TH is
only expressed in postmitotic neurons in the CNS, the CATH.a line
demonstrates that TH expression and continued cell division are not
incompatible after oncogenic transformation.
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