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Journal of Neuroscience, Vol 13, 1569-1576, Copyright © 1993 by Society for Neuroscience
Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily
PM Hwang, M Fotuhi, DS Bredt, AM Cunningham and SH Snyder
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
We have localized CDRK and DRK1, two novel K+ channels of the Shab
subfamily by immunohistochemistry. The two channels are closely related in
structure with about 90% amino acid identity in the N-terminal and middle
portions and 60% identity in the C-terminal region. We observe striking
differences in cellular localizations of the two channels. DRK1 tends to
localize to cell bodies and proximal dendrites discretely, while CDRK is
diffusely present in cell bodies and is also found on fibers in specific
brain areas. In the cerebral cortex DRK1 is localized to pyramidal cells,
whereas CDRK occurs in small cells, presumably interneurons. These
localizations may reflect specialized delayed rectifier functions and
targeting properties manifested differentially by K+ channel subfamily
members.
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