WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Seahorse Bioscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pike, C. J.
Right arrow Articles by Cotman, C. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pike, C. J.
Right arrow Articles by Cotman, C. W.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 13, 1676-1687, Copyright © 1993 by Society for Neuroscience

ARTICLE

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

CJ Pike, D Burdick, AJ Walencewicz, CG Glabe and CW Cotman
Irvine Research Unit in Brain Aging, University of California, Irvine 92717.

The progressive neurodegeneration of Alzheimer's disease has been hypothesized to be mediated, at least in part, by beta-amyloid protein. A relationship between the aggregation state of beta-amyloid protein and its ability to promote degeneration in vitro has been previously suggested. To evaluate this hypothesis and to define a structure- activity relationship for beta-amyloid, aggregation properties of an overlapping series of synthetic beta-amyloid peptides (beta APs) were investigated and compared with beta AP neurotoxic properties in vitro. Using light microscopy, electrophoresis, and ultracentrifugation assays, we found that few beta APs assembled into aggregates immediately after solubilization, but that over time peptides containing the highly hydrophobic beta 29-35 region formed stable aggregations. In short-term neuronal cultures, toxicity was associated specifically with those beta APs that also exhibited significant aggregation. Further, upon the partial reversal of beta 1-42 aggregation, a concomitant loss of toxicity was observed. A synthetic peptide derived from a different amyloidogenic protein, islet amyloid polypeptide, exhibited aggregation but not toxicity, suggesting that beta AP-induced neurotoxicity in vitro is not a nonspecific reaction to aggregated protein. The correlation between beta AP aggregation and neurotoxicity was also observed in long-term neuronal cultures but not in astrocyte cultures. These data are consistent with the hypothesis that beta-amyloid protein contributes to neurodegeneration in Alzheimer's disease.


This article has been cited by other articles:


Home page
 Biophys. JHome page
D. H. Kim and J. A. Frangos
Effects of Amyloid {beta}-Peptides on the Lysis Tension of Lipid Bilayer Vesicles Containing Oxysterols
Biophys. J., July 15, 2008; 95(2): 620 - 628.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. M. Hartley, C. Zhao, A. C. Speier, G. A. Woodard, S. Li, Z. Li, and T. Walz
Transglutaminase Induces Protofibril-like Amyloid {beta}-Protein Assemblies That Are Protease-resistant and Inhibit Long-term Potentiation
J. Biol. Chem., June 13, 2008; 283(24): 16790 - 16800.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Zhang, Y. Dong, G. Zhang, R. D. Moir, W. Xia, Y. Yue, M. Tian, D. J. Culley, G. Crosby, R. E. Tanzi, et al.
The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid {beta}-Protein Levels under Hypoxic Conditions
J. Biol. Chem., May 2, 2008; 283(18): 11866 - 11875.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Petratos, Q.-X. Li, A. J. George, X. Hou, M. L. Kerr, S. E. Unabia, I. Hatzinisiriou, D. Maksel, M.-I. Aguilar, and D. H. Small
The -amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism
Brain, January 1, 2008; 131(1): 90 - 108.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. J. Nelson and D. L. Alkon
Protection against beta-Amyloid-induced Apoptosis by Peptides Interacting with beta-Amyloid
J. Biol. Chem., October 26, 2007; 282(43): 31238 - 31249.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Takahashi, Y. Okamoto, H. A. Popiel, N. Fujikake, T. Toda, M. Kinjo, and Y. Nagai
Detection of Polyglutamine Protein Oligomers in Cells by Fluorescence Correlation Spectroscopy
J. Biol. Chem., August 17, 2007; 282(33): 24039 - 24048.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Verret, J. L. Jankowsky, G. M. Xu, D. R. Borchelt, and C. Rampon
Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis
J. Neurosci., June 20, 2007; 27(25): 6771 - 6780.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H.-g. Lee, X. Zhu, R. J. Castellani, A. Nunomura, G. Perry, and M. A. Smith
Amyloid-beta in Alzheimer Disease: The Null versus the Alternate Hypotheses
J. Pharmacol. Exp. Ther., June 1, 2007; 321(3): 823 - 829.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T.-V. V. Nguyen, M. Yao, and C. J. Pike
Flutamide and Cyproterone Acetate Exert Agonist Effects: Induction of Androgen Receptor-Dependent Neuroprotection
Endocrinology, June 1, 2007; 148(6): 2936 - 2943.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Necula, R. Kayed, S. Milton, and C. G. Glabe
Small Molecule Inhibitors of Aggregation Indicate That Amyloid beta Oligomerization and Fibrillization Pathways Are Independent and Distinct
J. Biol. Chem., April 6, 2007; 282(14): 10311 - 10324.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Xie, Y. Dong, U. Maeda, R. D. Moir, W. Xia, D. J. Culley, G. Crosby, and R. E. Tanzi
The Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Amyloid {beta}-Protein Accumulation
J. Neurosci., February 7, 2007; 27(6): 1247 - 1254.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Yao, T.-V. V. Nguyen, and C. J. Pike
Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against {beta}-Amyloid Peptide-Induced Neuronal Death
J. Neurosci., February 7, 2007; 27(6): 1422 - 1433.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Mendoza-Naranjo, C. Gonzalez-Billault, and R. B. Maccioni
Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases
J. Cell Sci., January 15, 2007; 120(2): 279 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
H. J. KIM, K. W. LEE, and H. J. LEE
Protective Effects of Piceatannol against Beta-Amyloid-Induced Neuronal Cell Death
Ann. N.Y. Acad. Sci., January 1, 2007; 1095(1): 473 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
H. Yu, J. Ren, and X. Qu
Time-Dependent DNA Condensation Induced by Amyloid {beta}-Peptide
Biophys. J., January 1, 2007; 92(1): 185 - 191.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
Z. Xie, Y. Dong, U. Maeda, R. Moir, S. K. Inouye, D. J. Culley, G. Crosby, and R. E. Tanzi
Isoflurane-Induced Apoptosis: A Potential Pathogenic Link Between Delirium and Dementia
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2006; 61(12): 1300 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
G. BU, J. CAM, and C. ZERBINATTI
LRP in Amyloid-beta Production and Metabolism
Ann. N.Y. Acad. Sci., November 1, 2006; 1086(1): 35 - 53.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang
Therapeutic approaches to Alzheimer's disease
Brain, November 1, 2006; 129(11): 2840 - 2855.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. V. Matveyenko and P. C. Butler
{beta}-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes.
Diabetes, July 1, 2006; 55(7): 2106 - 2114.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
V. Szegedi, G. Juhasz, E. Rozsa, G. Juhasz-Vedres, Z. Datki, L. Fulop, Z. Bozso, A. Lakatos, I. Laczko, T. Farkas, et al.
Endomorphin-2, an endogenous tetrapeptide, protects against A{beta}1-42 in vitro and in vivo
FASEB J, June 1, 2006; 20(8): 1191 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
B. Ma and R. Nussinov
The Stability of Monomeric Intermediates Controls Amyloid Formation: A{beta}25-35 and its N27Q Mutant
Biophys. J., May 15, 2006; 90(10): 3365 - 3374.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Brahmachari, Y. K. Fung, and K. Pahan
Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide.
J. Neurosci., May 3, 2006; 26(18): 4930 - 4939.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Qin, C. Colin, I. Hinners, A. Gervais, C. Cheret, and M. Mallat
System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40.
J. Neurosci., March 22, 2006; 26(12): 3345 - 3356.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. Santos, R. A. Quintanilla, A. Toro, R. Grandy, M. C. Dinamarca, J. A. Godoy, and N. C. Inestrosa
Peroxisomal Proliferation Protects from {beta}-Amyloid Neurodegeneration
J. Biol. Chem., December 9, 2005; 280(49): 41057 - 41068.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
S. C. MEREDITH
Protein Denaturation and Aggregation: Cellular Responses to Denatured and Aggregated Proteins
Ann. N.Y. Acad. Sci., December 1, 2005; 1066(1): 181 - 221.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Magrane, K. M. Rosen, R. C. Smith, K. Walsh, G. K. Gouras, and H. W. Querfurth
Intraneuronal {beta}-Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response
J. Neurosci., November 23, 2005; 25(47): 10960 - 10969.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. Hirata, H. Yamaguchi, Y. Takamura, A. Takagi, T. Fukushima, N. Iwakami, A. Saitoh, M. Nakagawa, and T. Yamada
A Novel Neurotrophic Agent, T-817MA [1-{3-[2-(1-Benzothiophen-5-yl) Ethoxy] Propyl}-3-azetidinol Maleate], Attenuates Amyloid-{beta}-Induced Neurotoxicity and Promotes Neurite Outgrowth in Rat Cultured Central Nervous System Neurons
J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 252 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
S. Lee, K. Carson, A. Rice-Ficht, and T. Good
Hsp20, a novel {alpha}-crystallin, prevents A{beta} fibril formation and toxicity
Protein Sci., March 1, 2005; 14(3): 593 - 601.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Yao, T.-V. V. Nguyen, and C. J. Pike
{beta}-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w
J. Neurosci., February 2, 2005; 25(5): 1149 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Jana and K. Pahan
Fibrillar Amyloid-{beta} Peptides Kill Human Primary Neurons via NADPH Oxidase-mediated Activation of Neutral Sphingomyelinase: IMPLICATIONS FOR ALZHEIMER'S DISEASE
J. Biol. Chem., December 3, 2004; 279(49): 51451 - 51459.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
M.-H. LI, J.-H. JANG, B. SUN, and Y.-J. SURH
Protective Effects of Oligomers of Grape Seed Polyphenols Against {beta}-Amyloid-Induced Oxidative Cell Death
Ann. N.Y. Acad. Sci., December 1, 2004; 1030(1): 317 - 329.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
J. R. Kim, A. Muresan, K. Y. C. Lee, and R. M. Murphy
Urea modulation of {beta}-amyloid fibril growth: Experimental studies and kinetic models
Protein Sci., November 1, 2004; 13(11): 2888 - 2898.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. D. Ciccotosto, D. Tew, C. C. Curtain, D. Smith, D. Carrington, C. L. Masters, A. I. Bush, R. A. Cherny, R. Cappai, and K. J. Barnham
Enhanced Toxicity and Cellular Binding of a Modified Amyloid {beta} Peptide with a Methionine to Valine Substitution
J. Biol. Chem., October 8, 2004; 279(41): 42528 - 42534.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
T. den Heijer, S. E Vermeer, E. J van Dijk, N. D Prins, P. J Koudstaal, C. M van Duijn, A. Hofman, and M. M. Breteler
Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia
Am. J. Clinical Nutrition, October 1, 2004; 80(4): 992 - 997.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. D. Tapp, C. T. Siwak, F. Q. Gao, J.-Y. Chiou, S. E. Black, E. Head, B. A. Muggenburg, C. W. Cotman, N. W. Milgram, and M.-Y. Su
Frontal Lobe Volume, Function, and {beta}-Amyloid Pathology in a Canine Model of Aging
J. Neurosci., September 22, 2004; 24(38): 8205 - 8213.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
F. G. DE FELICE, M. N. N. VIEIRA, L. M. SARAIVA, J. D. FIGUEROA-VILLAR, J. GARCIA-ABREU, R. LIU, L. CHANG, W. L. KLEIN, and S. T. FERREIRA
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of A{beta} oligomerization
FASEB J, September 1, 2004; 18(12): 1366 - 1372.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
C. Ege and K. Y. C. Lee
Insertion of Alzheimer's A{beta}40 Peptide into Lipid Monolayers
Biophys. J., September 1, 2004; 87(3): 1732 - 1740.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. H. Cribbs, W. W. Poon, R. A. Rissman, and M. Blurton-Jones
Caspase-Mediated Degeneration in Alzheimer's Disease
Am. J. Pathol., August 1, 2004; 165(2): 353 - 355.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Tong, R. Balazs, P. L. Thornton, and C. W. Cotman
{beta}-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons
J. Neurosci., July 28, 2004; 24(30): 6799 - 6809.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. M. Sigurdsson, E. Knudsen, A. Asuni, C. Fitzer-Attas, D. Sage, D. Quartermain, F. Goni, B. Frangione, and T. Wisniewski
An Attenuated Immune Response Is Sufficient to Enhance Cognition in an Alzheimer's Disease Mouse Model Immunized with Amyloid-{beta} Derivatives
J. Neurosci., July 14, 2004; 24(28): 6277 - 6282.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Harkany, C. Holmgren, W. Hartig, T. Qureshi, F. A. Chaudhry, J. Storm-Mathisen, M. B. Dobszay, P. Berghuis, G. Schulte, K. M. Sousa, et al.
Endocannabinoid-Independent Retrograde Signaling at Inhibitory Synapses in Layer 2/3 of Neocortex: Involvement of Vesicular Glutamate Transporter 3
J. Neurosci., May 26, 2004; 24(21): 4978 - 4988.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J. R. Kim and R. M. Murphy
Mechanism of Accelerated Assembly of {beta}-Amyloid Filaments into Fibrils by KLVFFK6
Biophys. J., May 1, 2004; 86(5): 3194 - 3203.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
D. J. Selkoe
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
Ann Intern Med, April 20, 2004; 140(8): 627 - 638.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-C. Suen, M.-S. Yu, K.-F. So, R. C.-C. Chang, and J. Hugon
Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/Threonine Protein Kinase in {beta}-Amyloid Peptide Neurotoxicity
J. Biol. Chem., December 12, 2003; 278(50): 49819 - 49827.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Murakami, K. Irie, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu, and T. Shirasawa
Neurotoxicity and Physicochemical Properties of A{beta} Mutant Peptides from Cerebral Amyloid Angiopathy: IMPLICATION FOR THE PATHOGENESIS OF CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE
J. Biol. Chem., November 14, 2003; 278(46): 46179 - 46187.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. J. Barnham, G. D. Ciccotosto, A. K. Tickler, F. E. Ali, D. G. Smith, N. A. Williamson, Y.-H. Lam, D. Carrington, D. Tew, G. Kocak, et al.
Neurotoxic, Redox-competent Alzheimer's {beta}-Amyloid Is Released from Lipid Membrane by Methionine Oxidation
J. Biol. Chem., October 31, 2003; 278(44): 42959 - 42965.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Kim, T. J. Gibson, and R. M. Murphy
Targeted Control of Kinetics of {beta}-Amyloid Self-association by Surface Tension-modifying Peptides
J. Biol. Chem., October 17, 2003; 278(42): 40730 - 40735.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Chalifour, R. W. McLaughlin, L. Lavoie, C. Morissette, N. Tremblay, M. Boule, P. Sarazin, D. Stea, D. Lacombe, P. Tremblay, et al.
Stereoselective Interactions of Peptide Inhibitors with the {beta}-Amyloid Peptide
J. Biol. Chem., September 12, 2003; 278(37): 34874 - 34881.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Bitan, S. S. Vollers, and D. B. Teplow
Elucidation of Primary Structure Elements Controlling Early Amyloid {beta}-Protein Oligomerization
J. Biol. Chem., September 12, 2003; 278(37): 34882 - 34889.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Gong, L. Chang, K. L. Viola, P. N. Lacor, M. P Lambert, C. E. Finch, G. A. Krafft, and W. L. Klein
Alzheimer's disease-affected brain: Presence of oligomeric A{beta} ligands (ADDLs) suggests a molecular basis for reversible memory loss
PNAS, September 2, 2003; 100(18): 10417 - 10422.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Y. Abramov, L. Canevari, and M. R. Duchen
Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity
J. Neurosci., June 15, 2003; 23(12): 5088 - 5095.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Qahwash, K. L. Weiland, Y. Lu, R. W. Sarver, R. F. Kletzien, and R. Yan
Identification of a Mutant Amyloid Peptide That Predominantly Forms Neurotoxic Protofibrillar Aggregates
J. Biol. Chem., June 13, 2003; 278(25): 23187 - 23195.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Hoshi, M. Sato, S. Matsumoto, A. Noguchi, K. Yasutake, N. Yoshida, and K. Sato
Spherical aggregates of {beta}-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3{beta}
PNAS, May 27, 2003; 100(11): 6370 - 6375.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Adessi, M.-J. Frossard, C. Boissard, S. Fraga, S. Bieler, T. Ruckle, F. Vilbois, S. M. Robinson, M. Mutter, W. A. Banks, et al.
Pharmacological Profiles of Peptide Drug Candidates for the Treatment of Alzheimer's Disease
J. Biol. Chem., April 11, 2003; 278(16): 13905 - 13911.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. E. Bamberger, M. E. Harris, D. R. McDonald, J. Husemann, and G. E. Landreth
A Cell Surface Receptor Complex for Fibrillar beta -Amyloid Mediates Microglial Activation
J. Neurosci., April 1, 2003; 23(7): 2665 - 2674.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. B. Stine Jr., K. N. Dahlgren, G. A. Krafft, and M. J. LaDu
In Vitro Characterization of Conditions for Amyloid-beta Peptide Oligomerization and Fibrillogenesis
J. Biol. Chem., March 21, 2003; 278(13): 11612 - 11622.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Buttini, G.-Q. Yu, K. Shockley, Y. Huang, B. Jones, E. Masliah, M. Mallory, T. Yeo, F. M. Longo, and L. Mucke
Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid beta Peptides But Not on Plaque Formation
J. Neurosci., December 15, 2002; 22(24): 10539 - 10548.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
S. Dante, T. Hauss, and N. A. Dencher
beta -Amyloid 25 to 35 Is Intercalated in Anionic and Zwitterionic Lipid Membranes to Different Extents
Biophys. J., November 1, 2002; 83(5): 2610 - 2616.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. A. Lashuel, D. M. Hartley, D. Balakhaneh, A. Aggarwal, S. Teichberg, and D. J. E. Callaway
New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE
J. Biol. Chem., November 1, 2002; 277(45): 42881 - 42890.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Urbanc, L. Cruz, R. Le, J. Sanders, K. H.