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Journal of Neuroscience, Vol 13, 1751-1758, Copyright © 1993 by Society for Neuroscience
Odorants differentially enhance phosphoinositide turnover and adenylyl cyclase in olfactory receptor neuronal cultures
GV Ronnett, H Cho, LD Hester, SF Wood and SH Snyder
Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Both the cAMP and the phosphoinositide (PI) second messenger systems have
been implicated in olfactory signal transduction. We have developed a
primary culture system of mammalian olfactory receptor neurons (ORNs;
Ronnett et al., 1991a) to permit analysis of odorant- induced second
messenger system activation in the intact ORN. The ability of a series of
odorants to stimulate PI turnover and adenylyl cyclase was examined. All
odorants stimulated both second messenger systems, although with
differential potencies. Stimulation of PI turnover desensitized upon
reexposure of cultures to odorant. The enhancement by single odorants of
both adenylyl cyclase and PI turnover, but to varying degrees, affords a
mechanism for increased specificity in olfactory signal transduction.
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