WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Seahorse Bioscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seki, T.
Right arrow Articles by Arai, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seki, T.
Right arrow Articles by Arai, Y.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 13, 2351-2358, Copyright © 1993 by Society for Neuroscience

ARTICLE

Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat

T Seki and Y Arai
Department of Anatomy, Juntendo University School of Medicine, Tokyo, Japan.

We have found in the adult rat that the persistent expression of a highly polysialylated neural cell adhesion molecule (NCAM-H) that is generally specific to developing tissues, remains restrictively in the cells of the deepest portion of the dentate granular layer. Since the granule cells are known to continue to be generated in this region during the adult period, we have tried to determine whether NCAM-H is expressed by newly generated granule cells. Immunoelectron microscopic observation revealed that about half of the NCAM-H-expressing cells had the features of dentate granule cells, and that the rest of these cells appeared to be immature cells. Double immunostaining for NCAM-H and glial fibrillary acidic protein (GFAP) revealed that the NCAM-H- expressing cells differed from GFAP-positive glial cells. In rats injected with 5-bromo-2'-deoxyuridine (BrdU) at post-natal day 35, double immunostaining for NCAM-H and BrdU demonstrated that the BrdU- labeled cells expressed NCAM-H at 12 d after the injection but not at 80 d. These results provide the first direct evidence that NCAM-H is expressed transiently by newly generated granule cells that may add new neuronal circuits to the adult hippocampal formation.


This article has been cited by other articles:


Home page
 Stem CellsHome page
A. Kerever, J. Schnack, D. Vellinga, N. Ichikawa, C. Moon, E. Arikawa-Hirasawa, J. T. Efird, and F. Mercier
Novel Extracellular Matrix Structures in the Neural Stem Cell Niche Capture the Neurogenic Factor Fibroblast Growth Factor 2 from the Extracellular Milieu
Stem Cells, September 1, 2007; 25(9): 2146 - 2157.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. D. Gray, M. Punsoni, N. E. Tabori, J. T. Melton, V. Fanslow, M. J. Ward, B. Zupan, D. Menzer, J. Rice, C. T. Drake, et al.
Methylphenidate Administration to Juvenile Rats Alters Brain Areas Involved in Cognition, Motivated Behaviors, Appetite, and Stress
J. Neurosci., July 4, 2007; 27(27): 7196 - 7207.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. Kimura, M. Ieda, H. Kanazawa, T. Yagi, M. Tsunoda, S.-i. Ninomiya, H. Kurosawa, K. Yoshimi, H. Mochizuki, K. Yamazaki, et al.
Cardiac Sympathetic Rejuvenation: A Link Between Nerve Function and Cardiac Hypertrophy
Circ. Res., June 22, 2007; 100(12): 1755 - 1764.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
N. Kaneko, H. Okano, and K. Sawamoto
Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb.
Genes Cells, October 1, 2006; 11(10): 1145 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
C. Florian, J. Foltz, J.-C. Norreel, G. Rougon, and P. Roullet
Post-training intrahippocampal injection of synthetic poly-{alpha}-2,8-sialic acid-neural cell adhesion molecule mimetic peptide improves spatial long-term performance in mice
Learn. Mem., May 1, 2006; 13(3): 335 - 341.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Heinrich, N. Nitta, A. Flubacher, M. Muller, A. Fahrner, M. Kirsch, T. Freiman, F. Suzuki, A. Depaulis, M. Frotscher, et al.
Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus.
J. Neurosci., April 26, 2006; 26(17): 4701 - 4713.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
X. Fontana, J. Nacher, E. Soriano, and J. A. del Rio
Cell Proliferation in the Adult Hippocampal Formation of Rodents and its Modulation by Entorhinal and Fimbria-Fornix Afferents
Cereb Cortex, March 1, 2006; 16(3): 301 - 312.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Maekawa, N. Takashima, Y. Arai, T. Nomura, K. Inokuchi, S. Yuasa, and N. Osumi
Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis
Genes Cells, October 1, 2005; 10(10): 1001 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J. Parkash and G. Kaur
Neuronal-glial plasticity in gonadotropin-releasing hormone release in adult female rats: role of the polysialylated form of the neural cell adhesion molecule
J. Endocrinol., August 1, 2005; 186(2): 397 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. N. Abrous, M. Koehl, and M. Le Moal
Adult Neurogenesis: From Precursors to Network and Physiology
Physiol Rev, April 1, 2005; 85(2): 523 - 569.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S.-i. Yoshihara, K. Omichi, M. Yanazawa, K. Kitamura, and Y. Yoshihara
Arx homeobox gene is essential for development of mouse olfactory system
Development, February 15, 2005; 132(4): 751 - 762.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
C. Sandi, M. I. Cordero, J. J. Merino, N. D. Kruyt, C. M. Regan, and K. J. Murphy
Neurobiological and Endocrine Correlates of Individual Differences in Spatial Learning Ability
Learn. Mem., May 1, 2004; 11(3): 244 - 252.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. S. Overstreet, S. T. Hentges, V. F. Bumaschny, F. S. J. de Souza, J. L. Smart, A. M. Santangelo, M. J. Low, G. L. Westbrook, and M. Rubinstein
A Transgenic Marker for Newly Born Granule Cells in Dentate Gyrus
J. Neurosci., March 31, 2004; 24(13): 3251 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Fukuda, F. Kato, Y. Tozuka, M. Yamaguchi, Y. Miyamoto, and T. Hisatsune
Two Distinct Subpopulations of Nestin-Positive Cells in Adult Mouse Dentate Gyrus
J. Neurosci., October 15, 2003; 23(28): 9357 - 9366.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. N. Abrous, W. Adriani, M.-F. Montaron, C. Aurousseau, G. Rougon, M. Le Moal, and P. V. Piazza
Nicotine Self-Administration Impairs Hippocampal Plasticity
J. Neurosci., May 1, 2002; 22(9): 3656 - 3662.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Gould and C. G. Gross
Neurogenesis in Adult Mammals: Some Progress and Problems
J. Neurosci., February 1, 2002; 22(3): 619 - 623.
[Full Text] [PDF]

Home page
 J. Virol.Home page
M. A. Passini and J. H. Wolfe
Widespread Gene Delivery and Structure-Specific Patterns of Expression in the Brain after Intraventricular Injections of Neonatal Mice with an Adeno-Associated Virus Vector
J. Virol., December 15, 2001; 75(24): 12382 - 12392.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Gould, N. Vail, M. Wagers, and C. G. Gross
Adult-generated hippocampal and neocortical neurons in macaques have a transient existence
PNAS, August 23, 2001; (2001) 181354698.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Nanobashvili, M. S. Airaksinen, M. Kokaia, J. Rossi, F. Asztely, K. Olofsdotter, P. Mohapel, M. Saarma, O. Lindvall, and Z. Kokaia
Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2
PNAS, October 24, 2000; 97(22): 12312 - 12317.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. T. KITTLER, E. V. GRIGORENKO, C. CLAYTON, S.-Y. ZHUANG, S. C. BUNDEY, M. M. TROWER, D. WALLACE, R. HAMPSON, and S. DEADWYLER
Large-scale analysis of gene expression changes during acute and chronic exposure to {Delta}9-THC in rats
Physiol Genomics, September 8, 2000; 3(3): 175 - 185.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. M. Parent, E. Tada, J. R. Fike, and D. H. Lowenstein
Inhibition of Dentate Granule Cell Neurogenesis with Brain Irradiation Does Not Prevent Seizure-Induced Mossy Fiber Synaptic Reorganization in the Rat
J. Neurosci., June 1, 1999; 19(11): 4508 - 4519.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Gould, A. J. Reeves, M. Fallah, P. Tanapat, C. G. Gross, and E. Fuchs
Hippocampal neurogenesis in adult Old World primates
PNAS, April 27, 1999; 96(9): 5263 - 5267.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Seki and U. Rutishauser
Removal of Polysialic Acid-Neural Cell Adhesion Molecule Induces Aberrant Mossy Fiber Innervation and Ectopic Synaptogenesis in the Hippocampus
J. Neurosci., May 15, 1998; 18(10): 3757 - 3766.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. M. Parent, T. W. Yu, R. T. Leibowitz, D. H. Geschwind, R. S. Sloviter, and D. H. Lowenstein
Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus
J. Neurosci., May 15, 1997; 17(10): 3727 - 3738.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Angata, J. Nakayama, B. Fredette, K. Chong, B. Ranscht, and M. Fukuda
Human STX Polysialyltransferase Forms the Embryonic Form of the Neural Cell Adhesion Molecule. TISSUE-SPECIFIC EXPRESSION, NEURITE OUTGROWTH, AND CHROMOSOMAL LOCALIZATION IN COMPARISON WITH ANOTHER POLYSIALYLTRANSFERASE, PST
J. Biol. Chem., March 14, 1997; 272(11): 7182 - 7190.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Windfuhr, A. Manegold, M. Muhlenhoff, M. Eckhardt, and R. Gerardy-Schahn
Molecular Defects That Cause Loss of Polysialic Acid in the Complementation Group 2A10
J. Biol. Chem., October 13, 2000; 275(42): 32861 - 32870.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Gould, N. Vail, M. Wagers, and C. G. Gross
Inaugural Article: Adult-generated hippocampal and neocortical neurons in macaques have a transient existence
PNAS, September 11, 2001; 98(19): 10910 - 10917.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-