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Journal of Neuroscience, Vol 13, 2382-2390, Copyright © 1993 by Society for Neuroscience
Primary structure, neural-specific expression, and dendritic location of human BC200 RNA
H Tiedge, W Chen and J Brosius
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029.
Primate BC200 RNA is a 200-nucleotide-long, nontranslatable RNA that is
prevalently expressed in the nervous system. We have determined the primary
structure of human BC200 RNA, using cDNA cloning and PCR techniques. BC200
RNA can be subdivided into three structural domains. The 5' region is
homologous to Alu repetitive elements that are found in high copy numbers
in primate genomes. The central part of BC200 RNA is characterized by a
high percentage of A-residues, with a few interspersed other nucleotides.
The 3' sequence is unique to BC200 RNA and shows no apparent similarity
with known human DNA sequences. Sequence similarity with rodent BC1 RNA is
limited to several short elements, and BC1/BC200 sequence comparisons
indicate that the two genes have evolved via separate phylogenetic routes.
Probes directed against the 3' unique part of BC200 RNA detected a single
band corresponding to approximately 200 nucleotides on RNA blots. This band
was identified only with RNA isolated from human brain, not with RNA from
non-neural organs such as lung or kidney. In situ hybridization to selected
areas of the human nervous system showed that BC200 RNA is expressed by a
subpopulation of neurons that is analogous to the BC1 RNA-expressing subset
of neurons in the corresponding areas of the rat nervous system. Moreover,
like rat BC1 RNA, human BC200 RNA was localized to dendrite-rich neuropil
areas, for example, in the inner plexiform layer of the retina. These
results indicate that BC1 RNA and BC200 RNA, although of different
evolutionary pedigree, may play analogous functional roles, in rodents and
primates, respectively, in somatodendritic domains of nerve cells.
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