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Journal of Neuroscience, Vol 13, 2477-2482, Copyright © 1993 by Society for Neuroscience
Associative long-term potentiation in piriform cortex slices requires GABAA blockade
ED Kanter and LB Haberly
Neuroscience Training Program, University of Wisconsin, Madison 53706.
Previous studies have demonstrated that NMDA-dependent, long-term
potentiation (LTP) can be induced in both afferent and intrinsic
association fiber systems in the piriform (primary olfactory) cortex. In
this report we demonstrate that an associative form of LTP can be induced
by coactivation of these two systems, which terminate on adjacent apical
dendritic segments of pyramidal cells. Potentiating stimulus trains were
delivered to either afferent or association fibers, and weak shocks, which
were nonpotentiating when delivered alone, were delivered to the other
pathway. Under control recording conditions where homosynaptic (single
pathway) LTP is consistently evoked, coincident application of these
stimuli failed to induce LTP of the weak shock response. However, after
local blockade of the fast, GABAA-mediated IPSP, associative LTP was
consistently produced in both directions. Induction was blocked by
D-2-amino-5-phosphonovaleric acid, indicating that it is dependent on
activation of NMDA receptors. It is speculated that afferent and
association fibers are segregated on different dendritic segments of
pyramidal cells in piriform cortex to allow regulation of associative LTP
by way of centrifugal inputs that modulate the activity of GABAergic
interneurons.
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