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Journal of Neuroscience, Vol 13, 2610-2616, Copyright © 1993 by Society for Neuroscience
Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons
G Dechant, A Rodriguez-Tebar, R Kolbeck and YA Barde
Department of Neurobiochemistry, Max Planck Institute for Psychiatry, Martinsried, Germany.
When used at concentrations allowing interactions only with its high-
affinity receptors, neurotrophin-3 (NT-3) promotes the survival of sensory
neurons isolated from embryonic day 8 (E8) chicks, but not the survival of
E11 sympathetic neurons. These sympathetic neurons (which can be rescued by
the addition of NGF) display high-affinity receptors for NT-3 (Kd of 1.6 x
10(-11) M) that cannot be distinguished from the high-affinity NT-3
receptors on sensory neurons using equilibrium binding or kinetic criteria.
This represents the first example of embryonic neurons that cannot be
rescued by the in vitro addition of a neurotrophin in spite of the presence
of corresponding neurotrophin high-affinity receptors. At elevated
concentrations, beyond the saturation of its high-affinity receptors, NT-3
supports the survival of some E11 sympathetic neurons, an effect that might
be mediated by the high-affinity NGF receptor. Using E7 sympathetic
neurons, about 40% of the cells initially plated can be rescued in vitro by
the addition of low concentrations of NT-3 (but not of NGF) and produce
profuse neurites. This indicates that NT-3 may play a role in the early
development of some sympathetic neurons.
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