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Journal of Neuroscience, Vol 13, 2730-2738, Copyright © 1993 by Society for Neuroscience
Motor axons preferentially reinnervate motor pathways
TM Brushart
Raymond M. Curtis Hand Center, Johns Hopkins University, Baltimore, Maryland 21205.
Motor axons regenerating after transection of mixed nerve preferentially
reinnervate distal motor branches and/or muscle, a process termed
"preferential motor reinnervation." Collaterals of a single motor axon
often enter both sensory and motor Schwann cell tubes of the distal stump;
specificity is generated by pruning collaterals from sensory pathways while
maintaining those in motor pathways. Previous experiments in the rat
femoral nerve model evaluated reinnervation of the femoral motor branch and
quadriceps muscle as a unit. In this study, pathway contributions are
analyzed separately by denying muscle contact, or by reinnervating muscle
through inappropriate, formerly sensory pathways. Motor axons
preferentially reinnervate motor pathways, even when these pathways end
blindly in a silicon tube. If the femoral nerve is removed as a graft and
reinserted with correct or reversed alignment of the sensory and motor
branches, more motoneurons reinnervate muscle through correct motor than
through incorrect sensory pathways. Motor pathways thus differ from sensory
pathways in ways that survive Wallerian degeneration and transplantation as
a graft, and that can be used by regenerating motor axons as a basis for
collateral pruning and specificity generation.
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