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Journal of Neuroscience, Vol 13, 2874-2888, Copyright © 1993 by Society for Neuroscience
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina
R Boos, H Schneider and H Wassle
Max-Planck-Institut fur Hirnforschung, Frankfurt, Germany.
All-amacrine cells are crucial interneurons in the rod pathway of the
mammalian retina. They receive input synapses from rod bipolar cells and
make electrical output synapses into the ON-pathway and glycinergic
chemical synapses into the OFF-pathway. Whole-cell currents from more than
50 voltage-clamped All-amacrine cells were recorded in a slice preparation
of the rat retina. The recorded cells were identified by intracellular
staining with Lucifer yellow. Spike-like potentials could be elicited upon
depolarization by current injection. A voltage- activated, fast,
TTX-sensitive, inward Na+ current was identified. A prominent outward K+
current could be suppressed by tetraethylammonium. GABA as well as glycine
activated Cl- channels, which could be blocked by bicuculline and
strychnine, respectively. Four agonists of excitatory amino acid
receptors--kainate (KA), AMPA, 2-amino-4- phosphonobutyrate (APB), and
NMDA--were tested. Inward currents at holding potentials of VH = -70 mV
were found by application of KA and AMPA but not by application of APB and
NMDA. These currents could be blocked by
6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). ACh did not evoke any current
responses.
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