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Journal of Neuroscience, Vol 13, 2889-2897, Copyright © 1993 by Society for Neuroscience
Differential expression of correlates of classical conditioning in identified medial and lateral type A photoreceptors of Hermissenda
RJ Frysztak and T Crow
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.
Classical conditioning of Hermissenda produces neurophysiological
correlates in the primary sensory neurons of the pathway mediating the
conditioned stimulus (CS), the type B and type A photoreceptors.
Biophysical and biochemical changes intrinsic to the type B photoreceptors
have been studied extensively in conditioned animals. A second site for
intrinsic modification with learning has been recently identified in type A
photoreceptors. We have recorded from identified medial and lateral type A
photoreceptors in conditioned animals and animals that received
pseudorandom presentations of light (CS) and rotation (unconditioned
stimulus). Here we report that conditioning produces differential effects
upon CS-elicited spike frequency and intrinsic excitability detected in
identified lateral and medial type A photoreceptors. Lateral type A
photoreceptors from conditioned animals exhibited significant increases in
spike frequency elicited by the CS as compared to pseudorandom controls. In
contrast, CS-elicited spike frequency recorded in medial type A
photoreceptors was not significantly different from random controls. The
amplitude of the peak and plateau phases of the generator potential of
medial and lateral type A photoreceptors was decreased in conditioned
animals as compared to random controls. In addition, only lateral type A
photoreceptors exhibited enhanced cellular excitability as expressed by
increased spike discharges produced by the injection of extrinsic
depolarizing current pulses. Conditioning also decreased spike frequency
accommodation in lateral type A photoreceptors. In normal controls, medial
type B photoreceptors produced stronger synaptic inhibition of medial type
A photoreceptors than the lateral type B photoreceptors inhibition of
lateral type A photoreceptors.(ABSTRACT TRUNCATED AT 250 WORDS)
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