 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 13, 2898-2909, Copyright © 1993 by Society for Neuroscience
Dihydropyridine-sensitive calcium current mediates neurotransmitter release from bipolar cells of the goldfish retina
M Tachibana, T Okada, T Arimura, K Kobayashi and M Piccolino
Department of Psychology, Faculty of Letters, University of Tokyo, Japan.
The release of neurotransmitter is evoked by activation of the Ca current
(ICa) at presynaptic terminals. Though multiple types of ICa have been
reported in various cells, little is known about the properties of
presynaptic ICa in the vertebrate CNS. The aim of this article is to
identify the type of ICa involved in the release of neurotransmitter from
retinal bipolar cells. Bipolar cells with a large axon terminal were
isolated enzymatically from the goldfish retina, and studied by the
following techniques: (1) recordings of ICa in the whole- cell recording
configuration, (2) visualization of intracellular free Ca2+ concentration
([Ca2+]i) with the Fura-2 imaging system, and (3) real-time
electrophysiological bioassay of released excitatory amino acid transmitter
by a voltage-clamped horizontal cell isolated from the catfish retina. The
only ICa found in bipolar cells was the high- voltage-activated,
dihydropyridine-sensitive type. This result supports the recent study by
Heidelberger and Matthews (1992). When ICa was activated by a short
depolarizing pulse, a rapid increase of [Ca2+]i was restricted to the axon
terminal. A much slower and smaller increase of [Ca2+]i was sometimes
observed at the cell body, probably due to the diffusion of intracellular
free Ca2+ from the axon terminal. The increase of [Ca2+]i was completely
suppressed by nicardipine, suggesting that Ca2+ entered through
dihydropyridine-sensitive Ca channels located mainly at the axon terminal.
Activating ICa of the bipolar cell evoked a transmitter-induced current in
the excitatory amino acid probe (i.e., the catfish horizontal cell). Both
currents were suppressed concomitantly by nifedipine but not by omega-
conotoxin.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
|
|
 
M. Hou, L. Duan, and M. M. Slaughter
Synaptic inhibition by glycine acting at a metabotropic receptor in tiger salamander retina
J. Physiol.,
June 15, 2008;
586(12):
2913 - 2926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Coggins, C. P. Grabner, W. Almers, and D. Zenisek
Stimulated exocytosis of endosomes in goldfish retinal bipolar neurons
J. Physiol.,
November 1, 2007;
584(3):
853 - 865.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Haeberle, M. Fujiwara, J. Chuang, M. M. Medina, M. V. Panditrao, S. Bechstedt, J. Howard, and E. A. Lumpkin
Molecular profiling reveals synaptic release machinery in Merkel cells
PNAS,
October 5, 2004;
101(40):
14503 - 14508.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nawy
Desensitization of the mGluR6 transduction current in tiger salamander On bipolar cells
J. Physiol.,
July 1, 2004;
558(1):
137 - 146.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Baumann, A. Gerstner, X. Zong, M. Biel, and C. Wahl-Schott
Functional Characterization of the L-type Ca2+ Channel Cav1.4{alpha}1 from Mouse Retina
Invest. Ophthalmol. Vis. Sci.,
February 1, 2004;
45(2):
708 - 713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Palmer, C. Hull, J. Vigh, and H. von Gersdorff
Synaptic Cleft Acidification and Modulation of Short-Term Depression by Exocytosed Protons in Retinal Bipolar Cells
J. Neurosci.,
December 10, 2003;
23(36):
11332 - 11341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Singer and J. S. Diamond
Sustained Ca2+ Entry Elicits Transient Postsynaptic Currents at a Retinal Ribbon Synapse
J. Neurosci.,
November 26, 2003;
23(34):
10923 - 10933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kreft, D. Krizaj, S. Grilc, and R. Zorec
Properties of Exocytotic Response in Vertebrate Photoreceptors
J Neurophysiol,
July 1, 2003;
90(1):
218 - 225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Heidelberger, P. Sterling, and G. Matthews
Roles of ATP in Depletion and Replenishment of the Releasable Pool of Synaptic Vesicles
J Neurophysiol,
July 1, 2002;
88(1):
98 - 106.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Berglund, M. Midorikawa, and M. Tachibana
Increase in the Pool Size of Releasable Synaptic Vesicles by the Activation of Protein Kinase C in Goldfish Retinal Bipolar Cells
J. Neurosci.,
June 15, 2002;
22(12):
4776 - 4785.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Heidelberger
ATP Is Required at an Early Step in Compensatory Endocytosis in Synaptic Terminals
J. Neurosci.,
September 1, 2001;
21(17):
6467 - 6474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Li, C. Thaler, and P. Brehm
Calcium Channels in Xenopus Spinal Neurons Differ in Somas and Presynaptic Terminals
J Neurophysiol,
July 1, 2001;
86(1):
269 - 279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Zenisek, D. Henry, K. Studholme, S. Yazulla, and G. Matthews
Voltage-Dependent Sodium Channels Are Expressed in Nonspiking Retinal Bipolar Neurons
J. Neurosci.,
July 1, 2001;
21(13):
4543 - 4550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nawy
Regulation of the On Bipolar Cell mGluR6 Pathway by Ca2+
J. Neurosci.,
June 15, 2000;
20(12):
4471 - 4479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Euler and R. H. Masland
Light-Evoked Responses of Bipolar Cells in a Mammalian Retina
J Neurophysiol,
April 1, 2000;
83(4):
1817 - 1829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Burrone and L. Lagnado
Synaptic Depression and the Kinetics of Exocytosis in Retinal Bipolar Cells
J. Neurosci.,
January 15, 2000;
20(2):
568 - 578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-H. Pan
Differential Expression of High- and Two Types of Low-Voltage-Activated Calcium Currents in Rod and Cone Bipolar Cells of the Rat Retina
J Neurophysiol,
January 1, 2000;
83(1):
513 - 527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Gomis, J. Burrone, and L. Lagnado
Two Actions of Calcium Regulate the Supply of Releasable Vesicles at the Ribbon Synapse of Retinal Bipolar Cells
J. Neurosci.,
August 1, 1999;
19(15):
6309 - 6317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release
Physiol Rev,
July 1, 1999;
79(3):
1019 - 1088.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hartveit
Reciprocal Synaptic Interactions Between Rod Bipolar Cells and Amacrine Cells in the Rat Retina
J Neurophysiol,
June 1, 1999;
81(6):
2923 - 2936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Krieger, A. Buschges, and A. el Manira
Calcium Channels Involved in Synaptic Transmission From Reticulospinal Axons in Lamprey
J Neurophysiol,
April 1, 1999;
81(4):
1699 - 1705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Edwards and H. T. Cline
Light-Induced Calcium Influx Into Retinal Axons Is Regulated by Presynaptic Nicotinic Acetylcholine Receptor Activity In Vivo
J Neurophysiol,
February 1, 1999;
81(2):
895 - 907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Job and L. Lagnado
Calcium and Protein Kinase C Regulate the Actin Cytoskeleton in the Synaptic Terminal of Retinal Bipolar Cells
J. Cell Biol.,
December 14, 1998;
143(6):
1661 - 1672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bonci, P. Grillner, N. B. Mercuri, and G. Bernardi
L-Type Calcium Channels Mediate a Slow Excitatory Synaptic Transmission in Rat Midbrain Dopaminergic Neurons
J. Neurosci.,
September 1, 1998;
18(17):
6693 - 6703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Matsui, N. Hosoi, and M. Tachibana
Excitatory Synaptic Transmission in the Inner Retina: Paired Recordings of Bipolar Cells and Neurons of the Ganglion Cell Layer
J. Neurosci.,
June 15, 1998;
18(12):
4500 - 4510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Protti and I. Llano
Calcium Currents and Calcium Signaling in Rod Bipolar Cells of Rat Retinal Slices
J. Neurosci.,
May 15, 1998;
18(10):
3715 - 3724.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Harada, C. Harada, M. Sekiguchi, and K. Wada
Light-Induced Retinal Degeneration Suppresses Developmental Progression of Flip-to-Flop Alternative Splicing in GluR1
J. Neurosci.,
May 1, 1998;
18(9):
3336 - 3343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Morgans, O. El Far, A. Berntson, H. Wassle, and W. R. Taylor
Calcium Extrusion from Mammalian Photoreceptor Terminals
J. Neurosci.,
April 1, 1998;
18(7):
2467 - 2474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Euler and H. Wassle
Different Contributions of GABAA and GABAC Receptors to Rod and Cone Bipolar Cells in a Rat Retinal Slice Preparation
J Neurophysiol,
March 1, 1998;
79(3):
1384 - 1395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kollmar, L. G. Montgomery, J. Fak, L. J. Henry, and A. J. Hudspeth
Predominance of the alpha 1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea
PNAS,
December 23, 1997;
94(26):
14883 - 14888.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Witkovsky, Y. Schmitz, A. Akopian, D. Krizaj, and D. Tranchina
Gain of Rod to Horizontal Cell Synaptic Transfer: Relation to Glutamate Release and a Dihydropyridine-Sensitive Calcium Current
J. Neurosci.,
October 1, 1997;
17(19):
7297 - 7306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mennerick, D. Zenisek, and G. Matthews
Static and Dynamic Membrane Properties of Large-Terminal Bipolar Cells From Goldfish Retina: Experimental Test of a Compartment Model
J Neurophysiol,
July 1, 1997;
78(1):
51 - 62.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
