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Journal of Neuroscience, Vol 13, 2930-2938, Copyright © 1993 by Society for Neuroscience
RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis
HJ Okano, DW Pfaff and RB Gibbs
Laboratory of Neurobiology and Behavior, Rockefeller University, New York, New York 10021.
Expression of the cell cycle regulatory proteins RB and p34cdc2 was
examined in the adult rat brain, with special emphasis on proliferation and
neuronal differentiation in the hippocampal formation and olfactory bulb.
RB-like immunoreactivity (RB-IR) was detected throughout the brain, with
particularly intense staining observed in hippocampal pyramidal cells,
pyriform cortex, and cerebellar Purkinje cells. Intense RB-IR and cdc2-IR
were also detected in proliferating neuronal precursor cells in the
subgranular region of the dentate gyrus and in the subependymal region
extending from the anterior lateral ventricle into the olfactory bulb. Many
of these cells developed into neurons as assessed by the expression of
neuron-specific enolase (NSE) and, in the hippocampal formation, the
expression of Fos-IR following pentylenetetrazol-induced seizure activity.
A good correlation was observed between the number of proliferating cells
expressing intense nuclear RB-IR staining and the number of
thymidine-labeled cells that had differentiated into functional hippocampal
neurons. A substantial decrease in RB-IR during differentiation was also
observed and occurred prior to the expression of NSE. The possibility that
the loss of RB may be necessary for neuronal differentiation to proceed is
discussed.
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