 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 13, 3136-3142, Copyright © 1993 by Society for Neuroscience
Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
SS Sisodia, EH Koo, PN Hoffman, G Perry and DL Price
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196.
Amyloid deposits are a characteristic feature of the senile plaques
identified in the brains of aged primates, individuals with Down's
syndrome, and cases of Alzheimer's disease. The beta-amyloid protein (A
beta), the principal component of amyloid, is a 4 kDa peptide derived from
larger amyloid precursor protein(s) (APP). Four mRNAs, generated by
alternative splicing of pre-mRNA derived from a single gene, encode A
beta-containing membrane glycoproteins termed APP-695, -714, -751, and
-770; the latter two isoforms contain a domain homologous to Kunitz
protease inhibitors (KPI). The present study uses in vitro and in vivo
strategies to examine the expression of APP in neurons of the dorsal root
ganglia and the nature of APP transported in sciatic nerves of rats. Using
quantitative in situ hybridization and semiquantitative PCR analysis, we
document that mRNAs encoding APP-695 are expressed preferentially over
transcripts that encode KPI-containing isoforms in rat sensory ganglia.
Furthermore, we provide compelling evidence that APP-695 is the predominant
isoform synthesized in sensory neurons of the rat PNS and that full-length
APP-695 and, to a lesser extent, APP- 751/770 are rapidly transported
anterogradely in axons.
This article has been cited by other articles:
|
|
|
|
 
H. Kaneko, A. Kakita, K. Kasuga, H. Nozaki, A. Ishikawa, A. Miyashita, R. Kuwano, G. Ito, T. Iwatsubo, H. Takahashi, et al.
Enhanced Accumulation of Phosphorylated {alpha}-Synuclein and Elevated -Amyloid 42/40 Ratio Caused by Expression of the Presenilin-1 {Delta}T440 Mutant Associated with Familial Lewy Body Disease and Variant Alzheimer's Disease
J. Neurosci.,
November 28, 2007;
27(48):
13092 - 13097.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. De Vos, A. L. Chapman, M. E. Tennant, C. Manser, E. L. Tudor, K.-F. Lau, J. Brownlees, S. Ackerley, P. J. Shaw, D. M. McLoughlin, et al.
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
Hum. Mol. Genet.,
November 15, 2007;
16(22):
2720 - 2728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Wang, L. Yang, Z. Wang, and H. Zheng
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
PNAS,
August 28, 2007;
104(35):
14140 - 14145.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Lazarov, G. A. Morfini, G. Pigino, A. Gadadhar, X. Chen, J. Robinson, H. Ho, S. T. Brady, and S. S. Sisodia
Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing Familial Alzheimer's Disease-Linked Mutant Presenilin 1
J. Neurosci.,
June 27, 2007;
27(26):
7011 - 7020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Saganich, B. E. Schroeder, V. Galvan, D. E. Bredesen, E. H. Koo, and S. F. Heinemann
Deficits in Synaptic Transmission and Learning in Amyloid Precursor Protein (APP) Transgenic Mice Require C-Terminal Cleavage of APP
J. Neurosci.,
December 27, 2006;
26(52):
13428 - 13436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Shaked, M. P. Kummer, D. C. Lu, V. Galvan, D. E. Bredesen, and E. H. Koo
A{beta} induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)
FASEB J,
June 1, 2006;
20(8):
1254 - 1256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. McGuire, J. Rong, S.-H. Li, and X.-J. Li
Interaction of Huntingtin-associated Protein-1 with Kinesin Light Chain: IMPLICATIONS IN INTRACELLULAR TRAFFICKING IN NEURONS
J. Biol. Chem.,
February 10, 2006;
281(6):
3552 - 3559.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Rockenstein, M. Mante, M. Alford, A. Adame, L. Crews, M. Hashimoto, L. Esposito, L. Mucke, and E. Masliah
High {beta}-Secretase Activity Elicits Neurodegeneration in Transgenic Mice Despite Reductions in Amyloid-{beta} Levels: IMPLICATIONS FOR THE TREATMENT OF ALZHEIMER DISEASE
J. Biol. Chem.,
September 23, 2005;
280(38):
32957 - 32967.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lleo, E. Waldron, C. A. F. von Arnim, L. Herl, M. M. Tangredi, I. D. Peltan, D. K. Strickland, E. H. Koo, B. T. Hyman, C. U. Pietrzik, et al.
Low Density Lipoprotein Receptor-related Protein (LRP) Interacts with Presenilin 1 and Is a Competitive Substrate of the Amyloid Precursor Protein (APP) for {gamma}-Secretase
J. Biol. Chem.,
July 22, 2005;
280(29):
27303 - 27309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Fryer, R. B. DeMattos, L. M. McCormick, M. A. O'Dell, M. L. Spinner, K. R. Bales, S. M. Paul, P. M. Sullivan, M. Parsadanian, G. Bu, et al.
The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice
J. Biol. Chem.,
July 8, 2005;
280(27):
25754 - 25759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I.-S. Yoon, C. U. Pietrzik, D. E. Kang, and E. H. Koo
Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid {beta} Protein Production via the {beta}-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling
J. Biol. Chem.,
May 20, 2005;
280(20):
20140 - 20147.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Lazarov, G. A. Morfini, E. B. Lee, M. H. Farah, A. Szodorai, S. R. DeBoer, V. E. Koliatsos, S. Kins, V. M.-Y. Lee, P. C. Wong, et al.
Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited
J. Neurosci.,
March 2, 2005;
25(9):
2386 - 2395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. T. Parent, N. Y. Barnes, Y. Taniguchi, G. Thinakaran, and S. S. Sisodia
Presenilin Attenuates Receptor-Mediated Signaling and Synaptic Function
J. Neurosci.,
February 9, 2005;
25(6):
1540 - 1549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Wang, G. Yang, D. R. Mosier, P. Chang, T. Zaidi, Y.-D. Gong, N.-M. Zhao, B. Dominguez, K.-F. Lee, W.-B. Gan, et al.
Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2
J. Neurosci.,
February 2, 2005;
25(5):
1219 - 1225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. U. Pietrzik, I.-S. Yoon, S. Jaeger, T. Busse, S. Weggen, and E. H. Koo
FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein
J. Neurosci.,
April 28, 2004;
24(17):
4259 - 4265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Cirrito, P. C. May, M. A. O'Dell, J. W. Taylor, M. Parsadanian, J. W. Cramer, J. E. Audia, J. S. Nissen, K. R. Bales, S. M. Paul, et al.
In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-{beta} Metabolism and Half-Life
J. Neurosci.,
October 1, 2003;
23(26):
8844 - 8853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-H. Kim, T. Ikeuchi, C. Yu, and S. S. Sisodia
Regulated Hyperaccumulation of Presenilin-1 and the "{gamma}-Secretase" Complex: EVIDENCE FOR DIFFERENTIAL INTRAMEMBRANOUS PROCESSING OF TRANSMEMBRANE SUBSTRATES
J. Biol. Chem.,
September 5, 2003;
278(36):
33992 - 34002.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Weggen, J. L. Eriksen, S. A. Sagi, C. U. Pietrzik, Todd. E. Golde, and E. H. Koo
A{beta}42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling through the APP Intracellular Domain
J. Biol. Chem.,
August 15, 2003;
278(33):
30748 - 30754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Inomata, Y. Nakamura, A. Hayakawa, H. Takata, T. Suzuki, K. Miyazawa, and N. Kitamura
A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1
J. Biol. Chem.,
June 13, 2003;
278(25):
22946 - 22955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ikeuchi, G. Dolios, S.-H. Kim, R. Wang, and S. S. Sisodia
Familial Alzheimer Disease-linked Presenilin 1 Variants Enhance Production of Both Abeta 1-40 and Abeta 1-42 Peptides That Are Only Partially Sensitive to a Potent Aspartyl Protease Transition State Inhibitor of "gamma -Secretase"
J. Biol. Chem.,
February 21, 2003;
278(9):
7010 - 7018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Cai, J. Y. Leem, J. P. Greenfield, P. Wang, B. S. Kim, R. Wang, K. O. Lopes, S.-H. Kim, H. Zheng, P. Greengard, et al.
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of beta -Amyloid Precursor Protein
J. Biol. Chem.,
January 24, 2003;
278(5):
3446 - 3454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Lazarov, M. Lee, D. A. Peterson, and S. S. Sisodia
Evidence That Synaptically Released beta -Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice
J. Neurosci.,
November 15, 2002;
22(22):
9785 - 9793.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. G. Sheng, D. L. Price, and V. E. Koliatsos
Disruption of Corticocortical Connections Ameliorates Amyloid Burden in Terminal Fields in a Transgenic Model of Abeta Amyloidosis
J. Neurosci.,
November 15, 2002;
22(22):
9794 - 9799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Yu, S.-H. Kim, T. Ikeuchi, H. Xu, L. Gasparini, R. Wang, and S. S. Sisodia
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment gamma . EVIDENCE FOR DISTINCT MECHANISMS INVOLVED IN gamma -SECRETASE PROCESSING OF THE APP AND Notch1 TRANSMEMBRANE DOMAINS
J. Biol. Chem.,
November 16, 2001;
276(47):
43756 - 43760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Brouillet, A. Trembleau, D. Galanaud, M. Volovitch, C. Bouillot, C. Valenza, A. Prochiantz, and B. Allinquant
The Amyloid Precursor Protein Interacts with Go Heterotrimeric Protein within a Cell Compartment Specialized in Signal Transduction
J. Neurosci.,
March 1, 1999;
19(5):
1717 - 1727.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Buxbaum, G. Thinakaran, V. Koliatsos, J. O'Callahan, H. H. Slunt, D. L. Price, and S. S. Sisodia
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
J. Neurosci.,
December 1, 1998;
18(23):
9629 - 9637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Sisodia and M. Gallagher
A role for the beta -amyloid precursor protein in memory?
PNAS,
October 13, 1998;
95(21):
12074 - 12076.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Y. Barnes, L. Li, K. Yoshikawa, L. M. Schwartz, R. W. Oppenheim, and C. E. Milligan
Increased Production of Amyloid Precursor Protein Provides a Substrate for Caspase-3 in Dying Motoneurons
J. Neurosci.,
August 1, 1998;
18(15):
5869 - 5880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhang, D. E. Kang, W. Xia, M. Okochi, H. Mori, D. J. Selkoe, and E. H. Koo
Subcellular Distribution and Turnover of Presenilins in Transfected Cells
J. Biol. Chem.,
May 15, 1998;
273(20):
12436 - 12442.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Lyckman, A. M. Confaloni, G. Thinakaran, S. S. Sisodia, and K. L. Moya
Post-translational Processing and Turnover Kinetics of Presynaptically Targeted Amyloid Precursor Superfamily Proteins in the Central Nervous System
J. Biol. Chem.,
May 1, 1998;
273(18):
11100 - 11106.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ikezu, B. D. Trapp, K. S. Song, A. Schlegel, M. P. Lisanti, and T. Okamoto
Caveolae, Plasma Membrane Microdomains for alpha -Secretase-mediated Processing of the Amyloid Precursor Protein
J. Biol. Chem.,
April 24, 1998;
273(17):
10485 - 10495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Thinakaran, C. L. Harris, T. Ratovitski, F. Davenport, H. H. Slunt, D. L. Price, D. R. Borchelt, and S. S. Sisodia
Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors
J. Biol. Chem.,
November 7, 1997;
272(45):
28415 - 28422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-H. Kim, Y.-K. Kim, S.-J. Jeong, C. Haass, Y.-H. Kim, and Y.-H. Suh
Enhanced Release of Secreted Form of Alzheimer's Amyloid Precursor Protein from PC12 Cells by Nicotine
Mol. Pharmacol.,
September 1, 1997;
52(3):
430 - 436.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N. R. Marquez-Sterling, A. C. Y. Lo, S. S. Sisodia, and E. H. Koo
Trafficking of Cell-Surface beta -Amyloid Precursor Protein: Evidence that a Sorting Intermediate Participates in Synaptic Vesicle Recycling
J. Neurosci.,
January 1, 1997;
17(1):
140 - 151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. Ikin, W. G. Annaert, K. Takei, P. De Camilli, R. Jahn, P. Greengard, and J. D. Buxbaum
Alzheimer Amyloid Protein Precursor Is Localized in Nerve Terminal Preparations to Rab5-containing Vesicular Organelles Distinct from Those Implicated in the Synaptic Vesicle Pathway
J. Biol. Chem.,
December 13, 1996;
271(50):
31783 - 31786.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. K. Lee, H. H. Slunt, L. J. Martin, G. Thinakaran, G. Kim, S. E. Gandy, M. Seeger, E. Koo, D. L. Price, and S. S. Sisodia
Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues
J. Neurosci.,
December 1, 1996;
16(23):
7513 - 7525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Torroja, L. Luo, and K. White
APPL, the Drosophila Member of the APP-Family, Exhibits Differential Trafficking and Processing in CNS Neurons
J. Neurosci.,
August 1, 1996;
16(15):
4638 - 4650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bouillot, A. Prochiantz, G.èv. Rougon, and B. Allinquant
Axonal Amyloid Precursor Protein Expressed by Neurons in Vitro Is Present in a Membrane Fraction with Caveolae-like Properties
J. Biol. Chem.,
March 29, 1996;
271(13):
7640 - 7644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Koo, S. Squazzo, D. Selkoe, and C. Koo
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody
J. Cell Sci.,
January 5, 1996;
109(5):
991 - 998.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Amaratunga and R. E. Fine
Generation of Amyloidogenic C-terminal Fragments during Rapid Axonal Transport in Vivo of [IMAGE]-Amyloid Precursor Protein in the Optic Nerve
J. Biol. Chem.,
July 21, 1995;
270(29):
17268 - 17272.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lai, S. S. Sisodia, and I. S. Trowbridge
Characterization of Sorting Signals in the beta-Amyloid Precursor Protein Cytoplasmic Domain
J. Biol. Chem.,
February 24, 1995;
270(8):
3565 - 3573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
