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Journal of Neuroscience, Vol 13, 3485-3495, Copyright © 1993 by Society for Neuroscience
Multiple receptor systems promote CNS neural migration
RB Fishman and ME Hatten
Rockefeller University, New York, New York 10021.
To identify glial receptor systems in CNS migration, cerebellar granule
neuron migration was assayed on glass fibers coated with polylysine,
astroglial membranes (AM fibers), or the extracellular matrix proteins
collagen (COLL fibers), fibronectin (FN fibers), and laminin (LAM fibers).
By video microscopy, granule cells migrated along AM fibers with the
cytology, neuron-fiber apposition, and dynamics seen on living glia. The
demonstration that immobilized astroglial membranes support neural
migration suggests that astroglial receptor systems, in combination with
glial fiber geometry, promote CNS neural migration. Moreover, granule
neurons migrated rapidly on LAM fibers, moved relatively slowly on FN
fibers, and not at all on COLL fibers. Antibody perturbation analyses
suggested that, whereas astrotactin provides the neural receptor for
migration on astroglial membranes, integrin beta 1 provides the neural
receptor for migration on LAM fibers. These results suggest that multiple
receptor systems support CNS neural migration.
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