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Journal of Neuroscience, Vol 13, 3549-3573, Copyright © 1993 by Society for Neuroscience
Development of individual geniculocortical arbors in cat striate cortex and effects of binocular impulse blockade
A Antonini and MP Stryker
W.M. Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco 94143.
This study analyzes the morphological changes in geniculocortical axons
terminating in the primary visual cortex of the cat, during the period in
which, in normal development, the terminals in layer IV undergo an
eye-specific segregation. Geniculocortical afferent fibers were filled
anterogradely by the Phaseolus lectin (PHA-L) injected into the main
laminae of the LGN. After standard immunohistochemical procedures, single
axons were serially reconstructed in two or three dimensions. Experiments
were performed in normal kittens and in kittens in which retinal activity
was continuously blocked by repeated intraocular injections of TTX. In
normal kittens, arbors were reconstructed at four different ages (19, 23,
30-31, and 39 days postnatally) spanning the period during which the
geniculocortical projection segregates into eye- specific columns in layer
IV (LeVay et al., 1978). Results reveal that sparse but widely extending
branches characteristic of young arbors are eliminated during normal
development at the same time as selected portions of the arbor grow
considerably in length and complexity. The terminal arborizations also
subdivide into distinct patches of terminals, consistent with the
segregation of left and right eye afferents. In TTX-treated animals, axonal
arbors reconstructed at postnatal days 23, 29, and 39 show a complexity and
extent of terminal arborization similar to that of normal animals, though
more variable in size and degree of elaboration. No progressive changes are
evident with age. Further, the majority of arbors reconstructed from
TTX-treated animals lack the patchy organization typical of normal animals.
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