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Journal of Neuroscience, Vol 13, 3712-3724, Copyright © 1993 by Society for Neuroscience
Postsynaptic targets of GABAergic hippocampal neurons in the medial septum-diagonal band of broca complex
K Toth, Z Borhegyi and TF Freund
Department of Functional Neuroanatomy, Hungarian Academy of Sciences, Budapest.
The termination pattern of hippocamposeptal nonpyramidal cells was
investigated by injecting Phaseolus vulgaris leucoagglutinin (PHAL) into
stratum oriens of the CA1 region. Electron microscopic analysis showed that
the majority of the anterogradely labeled boutons formed symmetric synapses
with dendrites and occasionally with cell bodies located in the medial
septum-diagonal band of Broca complex. We have demonstrated with
postembedding GABA immunocytochemistry that the majority of PHAL-labeled
axon terminals were GABAergic. The neurochemical character of the
postsynaptic target cells was also investigated using immunocytochemical
double staining. Our data showed that the majority of the labeled
hippocamposeptal axons innervated parvalbumin-immunoreactive cells
representing GABAergic projection neurons, and a smaller number of contacts
were found on ChAT-positive neurons. Septohippocampal neurons identified by
retrograde HRP transport were also shown to reactive direct
hippocamposeptal input. According to recent results, the lateral septum is
unlikely to relay the hippocampal feedback to the medial septum; therefore,
the direct hippocampal projection to the medial septum, arising from
GABAergic nonpyramidal cells, seems to be the only feedback pathway to the
area containing septohippocampal neurons. A novel circuit diagram, based on
our recent morphological-immunocytochemical findings, is shown for the
synaptic organization of the septo-hippocampo-septal loop. We suggest that
the GABAergic hippocamposeptal feedback controls the activity of septal
(mostly GABAergic) projection neurons as a function of hippocampal
synchrony. The newly discovered reciprocal interactions may give a better
insight into septohippocampal physiology.
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