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Journal of Neuroscience, Vol 13, 3802-3817, Copyright © 1993 by Society for Neuroscience
Spatial and behavioral correlates of striatal neurons in rats performing a self-initiated navigation task
SI Wiener
CNRS-College de France Laboratoire de Physiologie, Paris.
To investigate the spatial and behavioral correlates of striatal neurons
during displacement movements, the rostromedial dorsal striata (AP 1.0-2.2,
ML 1.5-2.0) of five rats were surgically implanted with advanceable bundles
of fine wire electrodes. After recovery, the rats were deprived of water
and trained in a square-walled open field in a dark room. The behavioral
task required alternating visits to water reservoirs in the center and in
the four corners. A certain corner contained the first reward for each
trial; after this reward, a cue card appeared in this corner for the rest
of the trial. The firing rates of striatal units were compared as the rat
moved between the center and the four corners of the arena. Analyses were
made of 30 units. Eight of these had firing rates that significantly
increased or decreased by 62-480% while the rat was in one or more
quadrants of the arena. Six of these manifested such firing rate changes
only as the rat performed certain behavioral sequences in the quadrant.
Three other units fired as the rat's head was in a certain orientation
relative to the arena walls, in all parts of the arena. To determine the
principal controlling cues and hence the frame of reference of spatial
selectivity of these units, the arena, while the rat was still inside, was
rotated in total darkness. The first water reward was then presented at the
same position relative to the outside room as before the rotation. The cue
card was then illuminated in this corner as a visual cue for the
extra-arena reference frame. All 11 neurons demonstrated spatial
selectivity that rotated with the arena; thus, this activity was in the
frame of reference of the arena and was not controlled by the visual cue.
Six other units fired at rates up to six times their resting discharge or
stopped firing completely in synchrony with initiation or execution of
displacement movements, and two of these were also location selective. Four
other units were silent as the rat performed the task, but fired tonically
following arena rotations or other interruptions of the session,
independent of the rat's location or movements. Nine analyzed units had
very low firing rates (< 1 impulse/sec) and showed no discernible
changes in activity as the rat performed the task. These patterns of unit
activity indicate that fundamental informational components required for
navigation are coded in the striatum.(ABSTRACT TRUNCATED AT 400 WORDS)
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