 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 13, 3839-3847, Copyright © 1993 by Society for Neuroscience
The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress
D Diorio, V Viau and MJ Meaney
Douglas Hospital Research Center, Department of Psychiatry, Montreal, Canada.
In the studies reported here we have examined the role of the medial
prefrontal cortex (MpFC) in regulating hypothalamic-pituitary-adrenal (HPA)
activity under basal and stressful conditions. In preliminary studies we
characterized corticosteroid receptor binding in the rat MpFC. The results
revealed high-affinity (Kd approximately 1 nM) binding with a moderate
capacity (42.9 +/- 3 fmol/mg) for 3H- aldosterone (with a 50-fold excess of
cold RU28362; mineralocorticoid receptor) and high-affinity (Kd
approximately 0.5-1.0 nM) binding with higher capacity (183.2 +/- 22
fmol/mg) for 3H-RU 28362 (glucocorticoid receptor). Lesions of the MpFC
(cingulate gyrus) significantly increased plasma levels of both
adrenocorticotropin (ACTH) and corticosterone (CORT) in response to a 20
min restraint stress. The same lesions had no effect on hormone levels
following a 2.5 min exposure to ether. Implants of crystalline CORT into
the same region of the MpFC produced a significant decrease in plasma
levels of both ACTH and CORT with restraint stress, but again, there was no
effect with ether stress. Neither MpFC lesions nor CORT implants had any
consistent effect on A.M. or P.M. levels of plasma ACTH or CORT.
Manipulations of MpFC function were not associated with changes in the
clearance rate for CORT or in corticosteroid receptor densities in the
pituitary, hypothalamus, hippocampus, or amygdala. Taken together, these
findings suggest that MpFC is a target site for the negative-feedback
effects of glucocorticoids on stress-induced HPA activity, and that this
effect is dependent upon the nature of the stress.
This article has been cited by other articles:
|
|
|
|
 
M. Adzic, J. Djordjevic, A. Djordjevic, A. Niciforovic, C. Demonacos, M. Radojcic, and M. Krstic-Demonacos
Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain
J. Endocrinol.,
July 1, 2009;
202(1):
87 - 97.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Radley, K. L. Gosselink, and P. E. Sawchenko
A Discrete GABAergic Relay Mediates Medial Prefrontal Cortical Inhibition of the Neuroendocrine Stress Response
J. Neurosci.,
June 3, 2009;
29(22):
7330 - 7340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kvetnansky, E. L. Sabban, and M. Palkovits
Catecholaminergic Systems in Stress: Structural and Molecular Genetic Approaches
Physiol Rev,
April 1, 2009;
89(2):
535 - 606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Weinberg, A. P. Bhatt, M. Girotti, C. V. Masini, H. E. W. Day, S. Campeau, and R. L. Spencer
Repeated Ferret Odor Exposure Induces Different Temporal Patterns of Same-Stressor Habituation and Novel-Stressor Sensitization in Both Hypothalamic-Pituitary-Adrenal Axis Activity and Forebrain c-fos Expression in the Rat
Endocrinology,
February 1, 2009;
150(2):
749 - 761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Furay, A. E. Bruestle, and J. P. Herman
The Role of the Forebrain Glucocorticoid Receptor in Acute and Chronic Stress
Endocrinology,
November 1, 2008;
149(11):
5482 - 5490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Radley, B. Williams, and P. E. Sawchenko
Noradrenergic Innervation of the Dorsal Medial Prefrontal Cortex Modulates Hypothalamo-Pituitary-Adrenal Responses to Acute Emotional Stress
J. Neurosci.,
May 28, 2008;
28(22):
5806 - 5816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Yang, L. H. Li, S. Y. Shin, S. Lee, S. Y. Lee, S. K. Han, and P. D. Ryu
Adrenalectomy Potentiates Noradrenergic Suppression of GABAergic Transmission in Parvocellular Neurosecretory Neurons of Hypothalamic Paraventricular Nucleus
J Neurophysiol,
February 1, 2008;
99(2):
514 - 523.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Gianaros, J. A. Horenstein, S. Cohen, K. A. Matthews, S. M. Brown, J. D. Flory, H. D. Critchley, S. B. Manuck, and A. R. Hariri
Perigenual anterior cingulate morphology covaries with perceived social standing
Soc Cogn Affect Neurosci,
September 1, 2007;
2(3):
161 - 173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Cerqueira, R. Taipa, H. B. M. Uylings, O. F. X. Almeida, and N. Sousa
Specific Configuration of Dendritic Degeneration in Pyramidal Neurons of the Medial Prefrontal Cortex Induced by Differing Corticosteroid Regimens
Cereb Cortex,
September 1, 2007;
17(9):
1998 - 2006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. F. Figueiredo, Y. M. Ulrich-Lai, D. C. Choi, and J. P. Herman
Estrogen potentiates adrenocortical responses to stress in female rats
Am J Physiol Endocrinol Metab,
April 1, 2007;
292(4):
E1173 - E1182.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Rozeboom, H. Akil, and A. F. Seasholtz
Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice
PNAS,
March 13, 2007;
104(11):
4688 - 4693.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Radley, C. M. Arias, and P. E. Sawchenko
Regional Differentiation of the Medial Prefrontal Cortex in Regulating Adaptive Responses to Acute Emotional Stress
J. Neurosci.,
December 13, 2006;
26(50):
12967 - 12976.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ahs, T. Furmark, A. Michelgard, B. Langstrom, L. Appel, O. T. Wolf, C. Kirschbaum, and M. Fredrikson
Hypothalamic Blood Flow Correlates Positively With Stress-Induced Cortisol Levels in Subjects With Social Anxiety Disorder
Psychosom Med,
November 1, 2006;
68(6):
859 - 862.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Jaferi and S. Bhatnagar
Corticosterone Can Act at the Posterior Paraventricular Thalamus to Inhibit Hypothalamic-Pituitary-Adrenal Activity in Animals that Habituate to Repeated Stress
Endocrinology,
October 1, 2006;
147(10):
4917 - 4930.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. L. Urry, C. M. van Reekum, T. Johnstone, N. H. Kalin, M. E. Thurow, H. S. Schaefer, C. A. Jackson, C. J. Frye, L. L. Greischar, A. L. Alexander, et al.
Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults.
J. Neurosci.,
April 19, 2006;
26(16):
4415 - 4425.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. J. MacLullich, K. J. Ferguson, J. M. Wardlaw, J. M. Starr, I. J. Deary, and J. R. Seckl
Smaller Left Anterior Cingulate Cortex Volumes Are Associated with Impaired Hypothalamic-Pituitary-Adrenal Axis Regulation in Healthy Elderly Men
J. Clin. Endocrinol. Metab.,
April 1, 2006;
91(4):
1591 - 1594.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Radley, A. B. Rocher, M. Miller, W. G.M. Janssen, C. Liston, P. R. Hof, B. S. McEwen, and J. H. Morrison
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Cereb Cortex,
March 1, 2006;
16(3):
313 - 320.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Karssen, O. C. Meijer, A. Berry, R. Sanjuan Pinol, and E. R. de Kloet
Low Doses of Dexamethasone Can Produce a Hypocorticosteroid State in the Brain
Endocrinology,
December 1, 2005;
146(12):
5587 - 5595.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Lee, L. R. Giles, W. L. Bryden, J. A. Downing, D. C. Collins, and P. C. Wynn
The effect of active immunization against adrenocorticotropic hormone on cortisol, {beta}-endorphin, vocalization, and growth in pigs
J Anim Sci,
October 1, 2005;
83(10):
2372 - 2379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Coryell, P. Nopoulos, W. Drevets, T. Wilson, and N. C. Andreasen
Subgenual Prefrontal Cortex Volumes in Major Depressive Disorder and Schizophrenia: Diagnostic Specificity and Prognostic Implications
Am J Psychiatry,
September 1, 2005;
162(9):
1706 - 1712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Cerqueira, J. M. Pego, R. Taipa, J. M. Bessa, O. F. X. Almeida, and N. Sousa
Morphological Correlates of Corticosteroid-Induced Changes in Prefrontal Cortex-Dependent Behaviors
J. Neurosci.,
August 24, 2005;
25(34):
7792 - 7800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Vandenborne, B. De Groef, S. M E Geelissen, E. R Kuhn, V. M Darras, and S. Van der Geyten
Corticosterone-induced negative feedback mechanisms within the hypothalamo-pituitary-adrenal axis of the chicken
J. Endocrinol.,
June 1, 2005;
185(3):
383 - 391.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Y. Zhang, P. Chretien, M. J. Meaney, and A. Gratton
Influence of Naturally Occurring Variations in Maternal Care on Prepulse Inhibition of Acoustic Startle and the Medial Prefrontal Cortical Dopamine Response to Stress in Adult Rats
J. Neurosci.,
February 9, 2005;
25(6):
1493 - 1502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. E. Ottowitz, D. D. Dougherty, A. Sirota, R. Niaura, S. L. Rauch, and W. A. Brown
Neural and Endocrine Correlates of Sadness In Women: Implications for Neural Network Regulation of HPA Activity
J Neuropsychiatry Clin Neurosci,
November 1, 2004;
16(4):
446 - 455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Bowman, N. J. MacLusky, Y. Sarmiento, M. Frankfurt, M. Gordon, and V. N. Luine
Sexually Dimorphic Effects of Prenatal Stress on Cognition, Hormonal Responses, and Central Neurotransmitters
Endocrinology,
August 1, 2004;
145(8):
3778 - 3787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sudo, Y. Chida, Y. Aiba, J. Sonoda, N. Oyama, X.-N. Yu, C. Kubo, and Y. Koga
Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
J. Physiol.,
July 1, 2004;
558(1):
263 - 275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Mizoguchi, A. Ishige, S. Takeda, M. Aburada, and T. Tabira
Endogenous Glucocorticoids Are Essential for Maintaining Prefrontal Cortical Cognitive Function
J. Neurosci.,
June 16, 2004;
24(24):
5492 - 5499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Froger, E. Palazzo, C. Boni, N. Hanoun, F. Saurini, C. Joubert, I. Dutriez-Casteloot, M. Enache, S. Maccari, N. Barden, et al.
Neurochemical and Behavioral Alterations in Glucocorticoid Receptor-Impaired Transgenic Mice after Chronic Mild Stress
J. Neurosci.,
March 17, 2004;
24(11):
2787 - 2796.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Cohen, Z. Kaplan, M. Kotler, I. Kouperman, R. Moisa, and N. Grisaru
Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in Posttraumatic Stress Disorder: A Double-Blind, Placebo-Controlled Study
Am J Psychiatry,
March 1, 2004;
161(3):
515 - 524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. F. Figueiredo, B. L. Bodie, M. Tauchi, C. M. Dolgas, and J. P. Herman
Stress Integration after Acute and Chronic Predator Stress: Differential Activation of Central Stress Circuitry and Sensitization of the Hypothalamo-Pituitary-Adrenocortical Axis
Endocrinology,
December 1, 2003;
144(12):
5249 - 5258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Tang, B. C. Reeb, R. D. Romeo, and B. S. McEwen
Modification of Social Memory, Hypothalamic-Pituitary-Adrenal Axis, and Brain Asymmetry by Neonatal Novelty Exposure
J. Neurosci.,
September 10, 2003;
23(23):
8254 - 8260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Shumake and F. Gonzalez-Lima
Brain Systems Underlying Susceptibility to Helplessness and Depression
Behav Cogn Neurosci Rev,
September 1, 2003;
2(3):
198 - 221.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Mattsson, M. Lai, J. Noble, E. McKinney, J. L. Yau, J. R. Seckl, and B. R. Walker
Obese Zucker Rats Have Reduced Mineralocorticoid Receptor and 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Expression in Hippocampus--Implications for Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis in Obesity
Endocrinology,
July 1, 2003;
144(7):
2997 - 3003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Verkuyl and M. Joels
Effect of Adrenalectomy on Miniature Inhibitory Postsynaptic Currents in the Paraventricular Nucleus of the Hypothalamus
J Neurophysiol,
January 1, 2003;
89(1):
237 - 245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. Laugero, F. Gomez, S. Manalo, and M. F. Dallman
Corticosterone Infused Intracerebroventricularly Inhibits Energy Storage and Stimulates the Hypothalamo-Pituitary Axis in Adrenalectomized Rats Drinking Sucrose
Endocrinology,
December 1, 2002;
143(12):
4552 - 4562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Francis, J. Diorio, P. M. Plotsky, and M. J. Meaney
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
J. Neurosci.,
September 15, 2002;
22(18):
7840 - 7843.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. F. Figueiredo, C. M. Dolgas, and J. P. Herman
Stress Activation of Cortex and Hippocampus Is Modulated by Sex and Stage of Estrus
Endocrinology,
July 1, 2002;
143(7):
2534 - 2540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Ziegler and J. P. Herman
Neurocircuitry of Stress Integration: Anatomical Pathways Regulating the Hypothalamo-Pituitary-Adrenocortical Axis of the Rat
Integr. Comp. Biol.,
July 1, 2002;
42(3):
541 - 551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. Laugero, M. E. Bell, S. Bhatnagar, L. Soriano, and M. F. Dallman
Sucrose Ingestion Normalizes Central Expression of Corticotropin-Releasing-Factor Messenger Ribonucleic Acid and Energy Balance in Adrenalectomized Rats: A Glucocorticoid-Metabolic-Brain Axis?
Endocrinology,
July 1, 2001;
142(7):
2796 - 2804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. H. Baeg, Y. B. Kim, J. Jang, H. T. Kim, I. Mook-Jung, and M. W. Jung
Fast Spiking and Regular Spiking Neural Correlates of Fear Conditioning in the Medial Prefrontal Cortex of the Rat
Cereb Cortex,
May 1, 2001;
11(5):
441 - 451.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Raber, S. F. Akana, S. Bhatnagar, M. F. Dallman, D. Wong, and L. Mucke
Hypothalamic-Pituitary-Adrenal Dysfunction in Apoe-/- Mice: Possible Role in Behavioral and Metabolic Alterations
J. Neurosci.,
March 1, 2000;
20(5):
2064 - 2071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Sullivan and A. Gratton
Lateralized Effects of Medial Prefrontal Cortex Lesions on Neuroendocrine and Autonomic Stress Responses in Rats
J. Neurosci.,
April 1, 1999;
19(7):
2834 - 2840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kollack-Walker, S. J. Watson, and H. Akil
Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain
J. Neurosci.,
November 15, 1997;
17(22):
8842 - 8855.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
