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Journal of Neuroscience, Vol 13, 4054-4063, Copyright © 1993 by Society for Neuroscience
mRNA at the synapse: analysis of a synaptosomal preparation enriched in hippocampal dendritic spines
ME Chicurel, DM Terrian and H Potter
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115.
Previous studies have demonstrated that the branched spines of the mossy
fiber-CA3 hippocampal synapse contain a particularly large number of
polyribosomes (Chicurel and Harris, 1989, 1992). We analyzed a preparation
of synaptosomes isolated from this region and have found it to contain a
restricted RNA population: certain mRNAs, presumably derived from the
dendritic spines and the fine astrocytic processes surrounding the pre- and
postsynaptic elements of the synapse, are enriched in the synaptosome
preparation as compared to the total hippocampus; other mRNAs are less
prevalent or altogether absent. In addition, neural BC1, a small noncoding
RNA thought to be involved in pre- or posttranslational regulatory
processes in dendrites, is a major RNA component of the dendritic spine.
These results support the hypothesis that local translational regulation of
gene expression may be important in establishing and modulating synaptic
function.
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