 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 124-133, Copyright © 1994 by Society for Neuroscience
Molecular plasticity of adult Bergmann fibers is associated with radial migration of grafted Purkinje cells
C Sotelo, RM Alvarado-Mallart, M Frain and M Vernet
INSERM U. 106, Hopital de la Salpetriere, Paris, France.
Embryonic Purkinje cells (PCs) from cerebellar primordia grafted in adult
pcd mutant cerebellum replace missing PCs of the host, and become
synaptically integrated into the defective cerebellar circuit. This process
of neuronal replacement starts with the invasion of grafted PCs into the
host cerebellum, and their radial migration through its molecular layer.
The present study is aimed at determining whether the glial axes for this
migration are embryonic radial glial cells that comigrate with the grafted
PCs, or adult Bergmann fibers of the host, transiently reexpressing the
molecular cues needed for their guidance of the migration. Transplants from
a transgenic mouse line (Krox- 20/lacZ14) in which Bergmann fibers could be
identified by lacZ expression reveal that, despite the presence of
X-gal-stained Bergmann fibers in the graft remnants and of grafted PCs in
the host molecular layer, all Bergmann fibers in the host cerebellum lack
of beta- galactosidase activity. Thus, these migratory axes belong to the
host, not to the donor. Transplants from normal isogenic mouse embryos show
that during the radial migration of grafted PCs (7 d after grafting) the
involved host Bergmann fibers reexpress nestin (identified with monoclonal
antibody Rat-401 immunostaining), normally expressed only by immature
Bergmann fibers. Five days later, when grafted PCs have arrested their
migration, host Bergmann fibers again become Rat-401 negative. These
results indicate that embryonic PCs can trigger in adult cerebellum the
molecular changes necessary for their own migration and ultimate synaptic
integration in the host cortical circuitry.
This article has been cited by other articles:
|
|
|
|
 
B. A. Emmenegger and R. J. Wechsler-Reya
Stem Cells and the Origin and Propagation of Brain Tumors
J Child Neurol,
October 1, 2008;
23(10):
1172 - 1178.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Messerschmidt, P. C. Brugger, E. Boltshauser, G. Zoder, W. Sterniste, R. Birnbacher, and D. Prayer
Disruption of Cerebellar Development: Potential Complication of Extreme Prematurity
AJNR Am. J. Neuroradiol.,
August 1, 2005;
26(7):
1659 - 1667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Canzoniere, S. Farioli-Vecchioli, F. Conti, M. T. Ciotti, A. M. Tata, G. Augusti-Tocco, E. Mattei, M. K. Lakshmana, V. Krizhanovsky, S. A. Reeves, et al.
Dual Control of Neurogenesis by PC3 through Cell Cycle Inhibition and Induction of Math1
J. Neurosci.,
March 31, 2004;
24(13):
3355 - 3369.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E J Mayer, E H Hughes, D A Carter, and A D Dick
Nestin positive cells in adult human retina and in epiretinal membranes
Br. J. Ophthalmol.,
September 1, 2003;
87(9):
1154 - 1158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Chazal, P. Durbec, A. Jankovski, G. Rougon, and H. Cremer
Consequences of Neural Cell Adhesion Molecule Deficiency on Cell Migration in the Rostral Migratory Stream of the Mouse
J. Neurosci.,
February 15, 2000;
20(4):
1446 - 1457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. W. Seeds, M. E. Basham, and S. P. Haffke
Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene
PNAS,
November 23, 1999;
96(24):
14118 - 14123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Dahmane and A Ruiz-i-Altaba
Sonic hedgehog regulates the growth and patterning of the cerebellum
Development,
January 6, 1999;
126(14):
3089 - 3100.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Anton, M. Marchionni, K. Lee, and P Rakic
Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex
Development,
January 9, 1997;
124(18):
3501 - 3510.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. Suzuki, N. Sato, M. Tohyama, A. Wanaka, and T. Takagi
cDNA Cloning of a Novel Membrane Glycoprotein That Is Expressed Specifically in Glial Cells in the Mouse Brain. LIG-1, A PROTEIN WITH LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS
J. Biol. Chem.,
September 13, 1996;
271(37):
22522 - 22527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kurtz, A. Zimmer, F. Schnutgen, G. Bruning, F. Spener, and T. Muller
The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
Development,
September 1, 1994;
120(9):
2637 - 2649.
[Abstract]
[PDF]
|
|
|
|
