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Journal of Neuroscience, Vol 14, 124-133, Copyright © 1994 by Society for Neuroscience
Molecular plasticity of adult Bergmann fibers is associated with radial migration of grafted Purkinje cells
C Sotelo, RM Alvarado-Mallart, M Frain and M Vernet
INSERM U. 106, Hopital de la Salpetriere, Paris, France.
Embryonic Purkinje cells (PCs) from cerebellar primordia grafted in adult
pcd mutant cerebellum replace missing PCs of the host, and become
synaptically integrated into the defective cerebellar circuit. This process
of neuronal replacement starts with the invasion of grafted PCs into the
host cerebellum, and their radial migration through its molecular layer.
The present study is aimed at determining whether the glial axes for this
migration are embryonic radial glial cells that comigrate with the grafted
PCs, or adult Bergmann fibers of the host, transiently reexpressing the
molecular cues needed for their guidance of the migration. Transplants from
a transgenic mouse line (Krox- 20/lacZ14) in which Bergmann fibers could be
identified by lacZ expression reveal that, despite the presence of
X-gal-stained Bergmann fibers in the graft remnants and of grafted PCs in
the host molecular layer, all Bergmann fibers in the host cerebellum lack
of beta- galactosidase activity. Thus, these migratory axes belong to the
host, not to the donor. Transplants from normal isogenic mouse embryos show
that during the radial migration of grafted PCs (7 d after grafting) the
involved host Bergmann fibers reexpress nestin (identified with monoclonal
antibody Rat-401 immunostaining), normally expressed only by immature
Bergmann fibers. Five days later, when grafted PCs have arrested their
migration, host Bergmann fibers again become Rat-401 negative. These
results indicate that embryonic PCs can trigger in adult cerebellum the
molecular changes necessary for their own migration and ultimate synaptic
integration in the host cortical circuitry.
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