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Journal of Neuroscience, Vol 14, 6488-6499, Copyright © 1994 by Society for Neuroscience
Age-dependent long-term potentiation of inhibitory synaptic transmission in rat visual cortex
Y Komatsu
Department of Physiology, Kyoto Prefectural University of Medicine, Japan.
Long-term potentiation (LTP) of inhibitory synaptic transmission in rat
visual cortex was investigated using intracellular recording in slice
preparations. The inhibitory postsynaptic potential (IPSP) of layer V cells
evoked monosynaptically by layer IV stimulation was recorded while
excitatory postsynaptic potentials (EPSPs) were blocked by adding NMDA and
non-NMDA receptor antagonists to the perfusate. Separate presynaptic fiber
groups were activated by two stimulating electrodes placed in layer IV. One
electrode was used to test the effect of conditioning stimulation; the
other served as a control. Trains of high- frequency stimulation (50 Hz, 1
sec) were applied at an interval of 10 sec as a conditioning stimulation.
The LTP of IPSP induced by the conditioning stimulation had properties
similar to those known for LTP of EPSP in hippocampal CA1: (1) it was
specific to the conditioned pathway; (2) repetitive application of the
conditioning stimulation saturated the LTP; (3) LTP was induced by
conditioning stimulation at intensities higher than a threshold; (4) weak
conditioning stimulation to one pathway, which alone failed to induce LTP,
induced associative LTP when strong conditioning stimulation was
simultaneously applied to the other pathway; (5) weak conditioning
stimulation sometimes induced short-term potentiation. In contrast to these
similarities, LTP of IPSP was induced by a wider range of stimulus
frequencies than that capable of generating LTP of EPSPs in CA1. It was
induced not only by a brief high-frequency stimulation but also by an
intermediate-frequency (2 Hz) stimulation continued for 5 min. In addition,
the LTP induction was not dependent on postsynaptic membrane potential.
Finally, the LTP of IPSP was more easily induced in developing than in
mature rats. This age dependence suggests that LTP of IPSPs may contribute
to the improvement of response selectivity of visual cortical cells through
visual experience during postnatal development.
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