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Journal of Neuroscience, Vol 14, 6779-6795, Copyright © 1994 by Society for Neuroscience
Squirrel monkey lateral thalamus. I. Somatic nociresponsive neurons and their relation to spinothalamic terminals
AV Apkarian and T Shi
Department of Neurosurgery, SUNY Health Science Center, Syracuse 13210.
The incidence and response properties of nociresponsive neurons, their
locations relative to spinothalamic terminals, and their relations to
cytoarchitectonic borders were studied in the lateral thalamus of the
squirrel monkey. Nociceptive neurons were found in ventral posterior
inferior nucleus (VPI), in the lateral and medial nuclei (VPL and VPM) of
the ventral posterior complex (VP = VPL + VPM), as well as the posterior
complex (PO). The overall incidence of nociresponsive cells was 19% (50 of
270 cells). The proportion of nociresponsive neurons within VPI was 50% (23
of 46), 38% in PO (8 of 21), and 10% in VP (19 of 203). Most nociresponsive
cells (90%) in VP were of wide-dynamic- range type, while within VPI 43% of
nociresponsive cells were nociceptive-specific type. Most of these
nociresponsive cells had thermal and mechanical responses, and a small
number also responded to cooling. The receptive fields of nociresponsive
cells in VPL were in continuity, in both size and body location, with
surrounding low- threshold units. The receptive fields of VPI and PO
nociresponsive cells were larger than those in VPL. The probability of
encountering nociresponsive cells located within 100 microns of
spinothalamic terminations was high in VPI (73%) and low in VPL (33%). On
the other hand, the probability of encountering non-nociceptive cells
located within 100 microns of spinothalamic terminals was low in both VPI
(20%) and VPL (26%). The results indicate segregation of nociresponsive
cell types across VP, VPI, and PO and suggest that VPI, and perhaps PO, is
an important region for discriminative processing and perception of painful
stimuli.
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