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Journal of Neuroscience, Vol 14, 6796-6814, Copyright © 1994 by Society for Neuroscience
Squirrel monkey lateral thalamus. II. Viscerosomatic convergent representation of urinary bladder, colon, and esophagus
J Bruggemann, T Shi and AV Apkarian
Department of Neurosurgery, SUNY Health Science Center at Syracuse 13210.
The response properties of 106 visceroceptive lateral thalamic neurons were
investigated in anesthetized squirrel monkeys. Most neurons were located in
the ventral posterior lateral nucleus (VPL), and a smaller number of cells
was also found in a variety of thalamic nuclei around VPL. Ninety (85%) of
these cells responded to distension of the urinary bladder, the distal
colon, and/or the lower esophagus. The majority of the visceral-responsive
cells also had convergent somatic and multivisceral responses (71% of the
85%). A small population (6%) was visceral specific; that is, these neurons
were not activated with somatic stimuli. Visceral responses were
excitatory, inhibitory, or mixed, and most were either visceral nociceptive
specific (65%) or visceral wide-dynamic-range type (34%). Very few visceral
responses (1%) could be classified as low threshold. The incidence of these
response types were highly dependent on the specific viscus stimulated.
Most visceral responses were able to code stimulus duration and intensity.
The majority (69%) of the visceroceptive neurons had somatic low-threshold
convergent input mainly from the surface of the lower body. The somatic
receptive field locations and the somatic response properties seem
unrelated to the convergent visceral input and the visceral response
properties, although there were some exceptions. No obvious viscerotopical
organization was found in VPL. The results lead us to propose two different
modes of representation for processing of and distinguishing between
visceral and somatic inputs: a distributed population code for visceral
inputs, and a local code for somatic inputs. Based on these codes, we
discuss a new hypothesis for referred pain.
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